Acute interstitial nephritis
Conditions
Interventions
Patients will be randomly categorized in to four groups by computer generated randomization sequence
Each category will receive two drugs as follows, starting from the day after biopsy.
Category 1:
Sponsors
None
Eligibility
Inclusion criteria
Inclusion criteria: 1. Two or more elevated (value more than upper limit of the normal) serum creatinine values done within 3 days and 2. Normal size kidneys defined as more than 9 cm longitudinal diameter and normal anatomy on ultrasound scan 3. Age less than 60 years
Exclusion criteria
Exclusion criteria: 1. History of chronic kidney disease, diabetes mellitus, chronic hypertension, connective tissue diseases, vacuities,hyperuricemia, pyelonephritis, renal stone disease and any obstructive uropathy, polycystic kidney disease or any other known genetic disease, glomerular nephritides, snake bite, and childhood renal disease. 2. Whose current abnormal creatinine is explainable by recent exposure to nephrotoxic drugs (non-steroidal anti-inflammatory drugs, gentamicin…etc.) or toxins. 3. BP >160/100mmhg untreated or >140/90 on up to two antihypertensives 4. Two or more fasting blood sugar more than 7 mmol/l 5. UFR showing red blood cells more 50 per HPF with more than 80% dysmorphic cells or nephrotic range proteinuria or pus cells more than 100 per HPF with a positive urine culture 6. Ultrasound scan revealing unilateral renal involvement
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum creatinine [2 weeks, one month, six month, two years] | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Reaching stage 4 kidney disease 2. Death 3. Small contracted kidneys [6months, 2 years] | — |
Countries
Sri Lanka
Contacts
Public ContactNishantha Nanayakkara
Consultant Nephrologist
Outcome results
None listed