Postoperative pain in thoracic surgery
Conditions
Interventions
Patients undergoing thoracic surgery will be randomized into 2 groups. The first group will receive continuous epidural infusion of 10%MgSO4. The second group will receive continuous epidural infusion
Sponsors
Department of Anesthesia and Intensive Care
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients, ASA class I-III undergoing elective thoracic surgery
Exclusion criteria
Exclusion criteria: Patients with renal or hepatic failure, patients with neuromuscular disorders, AV block II-III degree, morbidly obese and patients preoperatively treated with opioids or calcium channel blockers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Intraoperative cumulative doses of anesthetic (propofol), muscle relaxant (rocuronium) and analgesic (sufentanil) 2. Cumulative epidural doses of local anesthetic (levobupivacain) and analgetic (sufentanil) during first 48hours. 3. Plasma levels of magnesium 4. Plasma levels of cortisol [1. At the end of the operative period 2. At the end of 48 hours 3. Plasma level of magnesium: preoperatively, at the end of the procedure and every 8 hours during first 24 hours. 4. Plasma level of cortisol: before premedication, 1 hour after the start of the operation, 1 hour after the end of the operation and first postoperative day ] | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Pain perception using changes in VAS and TORDA scores 2. Incidence of chronic postthoracotomy pain [1. VAS and TORDA scores will be evaluated every 4 hours during first 48 hours post operatively 2. Incidence of chronic post-thoracotomy pain will be evaluated 6 months after the surgical procedure ] | — |
Countries
Croatia
Contacts
Public ContactJana Kogler M.D.
Outcome results
None listed