Non-dermatophyte onychomycosis
Conditions
Interventions
Consenting patients will be randomized into two arms. The first arm (A) will receive oral Itraconazole pulse therapy (i.e. itraconazole 200 mg twice daily for 7 days per month
1 week on and 3 weeks off). Two pulses will be given for fingernail infections and three pulses for toenail infections. The second arm (B) will receive Terbinafine pulse therapy: terbinafine 250mg twi
1 week on and 3 weeks off). Two pulses will be given for fingernail infections and three pulses for toenail infections
Sponsors
Base Hospital Homagama
Eligibility
Inclusion criteria
Inclusion criteria: All patients with non-dermatophyte mycology as confirmed by fungal studies will be recruited
Exclusion criteria
Exclusion criteria: 1. >12 years of age 2. pregnancy 3. breast feeding 4. known renal impairment 5. known liver impairment 6. congestive cardiac failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical cure (morphologically normal nail) [At 12 weeks for fingernail infections and 16 weeks for toenail infections] Mycological cure (negative light microscopic examination [KOH] and negative fungal culture) [At 12 weeks for fingernail infections and 16 weeks for toenail infections] | — |
Secondary
| Measure | Time frame |
|---|---|
| Long term clinical cure (morphologically normal nail) [For fingernail infections: every 12 weeks for a total 14 months For toenail infections: every 12 weeks for a total 15 months ] Long term Mycological cure (negative light microscopic examination [KOH] and negative fungal culture) [For fingernail infections: every 12 weeks for a total 14 months For toenail infections: every 12 weeks for a total 15 months ] | — |
Countries
Sri Lanka
Contacts
Public ContactRanthilaka Ranawaka
Consultant Dermatologist
Outcome results
None listed