Dengue fever
Conditions
Interventions
Consenting patients will be randomized into treatment and control groups. The treatment group will be given Carica papaya leaf extract. The extract will be prepared by crushing fresh mature Papaya lea
Sponsors
None
Eligibility
Inclusion criteria
Inclusion criteria: Male and female patients admitted to the university medical unit at Colombo South Teaching Hospital fulfilling ALL the following criteria will be included in this study. (1) >18 and <60 years of age (2) Acute onset of fever (3) Platelet count <150,000 per cu.mm and / or Hct elevated by 5% and / or white cell count <5000/cu.mm. (4) Dengue IgM positive after 7 days of illness
Exclusion criteria
Exclusion criteria: (1) History of allergy to papaya (2)Pregnancy (3)Patients who have already taken papaya juice extracts before admitting to hospital (4) Patients with previously diagnosed abnormal clotting profile as per past history and medical records (5) Patients suffering from any other illnesses which will influence the course of dengue fever. (6) Patients suffering from any other illnesses or on drugs which will influence the bone marrow function or haemopoitic system. (7) Dengue patients who are being treated with blood products. (8) Patients with severe hemorrhagic dengue (9) Dengue IgM negative after 7 days of the illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| White blood cell count (WBC) / Differential counts [At recruitment and daily until discharge ] The platelet count [At recruitment and daily until discharge ] Haematocrit [At recruitment and daily until discharge ] The prothrombin time (PT) [At recruitment and daily until discharge ] Alanine aminotransferase (ALT) [At recruitment and daily until discharge ] Presence of pleural effusion [At recruitment and daily until discharge ] Serum cholesterol [At recruitment and daily until discharge ] CD 4 counts [Before ingestion of first dose and after completing 3 days of treatment] | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of hospital stay [At discharge] | — |
Countries
Sri Lanka
Contacts
Public ContactDr. Sanath Hettige
Consultant Family physician
Outcome results
None listed