Postoperative pain after lumbotomy incision
Conditions
Interventions
Patients undergoing lumbotomy will be randomized into 3 groups. The first group will receive continuous intravenous infusion of sufentanil and ketamine. The second group will receive continuous epidur
Sponsors
The Ministry of Science, Education, and Sports of the Republic of Croatia
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients (aged more than 18 years) ASA I and II undergoing open kidney surgery with lumbotomy (nephrectomy, nephrolithotomy, pyeloplastic surgery, kidney resection, adrenalectomy).
Exclusion criteria
Exclusion criteria: Patients with ASA III and IV, diabetes mellitus, advanced cancer, psychiatric disorders, cognitive deficits, and taking immunosupressive therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences between three groups in the levels of metabolic markers (leukocyte count, lymphocyte count, CRP, fibrinogen, and blood glucose), stress hormones (prolactin, cortisol, adrenalin), and cytokines (interleukin IL-1, IL-6, IL-1RA). [Preoperatively and 4, 24, and 48 hours after induction of analgesia.] | — |
Secondary
| Measure | Time frame |
|---|---|
| Decrease in the visual analogue scale (VAS) score; changes in clinical status (ECG, SaO2, BP, HR), and occurence of complications (atelectasis, pneumonia). [Every 4 hours in the first 48 hours postoperatively.] | — |
Countries
Croatia
Contacts
Public ContactVilka Bekavac Misak M.D.
Outcome results
None listed