Graves' thyrotoxicosis
Conditions
Interventions
Randomized controlled prospective clinical trial conducted at the medical clinics of the University Medical Unit, National Hospital of Sri Lanka, Diabetes Research Unit and private sector medical cons
Sponsors
MSJ industries (Ceylon) (Pvt/ltd)
Eligibility
Inclusion criteria
Inclusion criteria: All males and females with newly diagnosed Graves' thyrotoxicosis attending to the clinics mentioned above who are in the 18-70yrs age group Criteria for diagnosis of Graves' disease - Signs and symptoms of Graves' hyperthyroidism; Diffusely enlarged goiter; Elevated thyroid hormones; Free T4 - Suppressed TSH levels enlarged goiter
Exclusion criteria
Exclusion criteria: - Other types of thyrotoxicosis (toxic multinodular goiter, toxic adenoma) - Pregnancy - Breast feeding - Recurrent hyperthyroidism - Patients who have undergone radio iodine treatment or treatment with Lugol's iodine - Patients who are on medications known to interfere with thyroid functions – eg. lithium, amioradone, thyroxine, beta blockers, oral contraceptive pills, oestrogen containing agents, glucocorticoids - Impaired liver functions - Impaired renal functions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Normalization of free T4 [End of 4 weeks of treatment] | — |
Secondary
| Measure | Time frame |
|---|---|
| Normalization of serum TSH and FT3, rate of response of the drugs, reduction of the FT4 by a unit measurement of the drug [At 4, 8 and 12 weeks after starting treatment] | — |
Countries
Sri Lanka
Contacts
Public ContactDr. Dinithi Fernando
Senior Lecturer
Outcome results
None listed