Effects of isosorbide mononitrate for pre-induction cervical ripening
Conditions
Interventions
Women will be randomly allocated to three groups by using stratified (primi/multi) block randomization and ISMN - SR 60mg will be inserted for 2 days (group 1) and 3 days (group 2) vaginally. Women in
Sponsors
University of Ruhuna, Faculty of Medicine
Eligibility
Inclusion criteria
Inclusion criteria: Consecutive women with uncomplicated singleton pregnancies having a cephalic presentation at period of gestation of 40 weeks and 3 days and having modified Bishop's score < 6.
Exclusion criteria
Exclusion criteria: *Complicated pregnancies – both maternal or fetal complications *Pregnancies with uncertain dates not confirmed by early scan, even though clinically considered as 41 weeks. Multiple pregnancies *Pregnancies with contraindication for normal vaginal delivery *Pregnancies with previous caesarean section. Any contraindication for the use of ISMN.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Establishment of spontaneous onset of labour within 72 hours [72 hours] Change in mean modified Bishop's score after 72 hours [72 hours] Favorable induction of labour after 72 hours. [72 hours] | — |
Secondary
| Measure | Time frame |
|---|---|
| Induction to delivery interval. [After delivery] Mode of delivery. [After delivery] Side effects of ISMN therapy. [After delivery] Acceptance of outpatient self administration of therapy. [After delivery] | — |
Countries
Sri Lanka
Contacts
Public ContactProf. Malik Goonewardene
Professor and Head
Outcome results
None listed