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Prevention of antivenom reactions by administering intravenous hydrocortosne 2 hours before antivenom treatment

Efficacy of intravenous hydrocortisone administered 2 hours prior to antivenom as prophylaxis against adverse reactions to snake antivenom in Sri Lanka

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
SLCTR
Registry ID
SLCTR/2010/005
Enrollment
Unknown
Registered
2010-07-02
Start date
2010-06-06
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Snake bite,antivenom reactions

Interventions

Bolus intravenous hydrocortisone 500mg administered minimum of 2 hours before antivenom

Sponsors

Prof SAM Kularatne
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Proven snake bites (with the specimen of the offending snake or evidence based diagnosis of snake bite) 2. Antivenom is indicated. 3. Above 12 years of age.

Exclusion criteria

Exclusion criteria: 1. Patients who had already received hydrocortisone, antihistamines or adrenaline as prophylaxis, snake antivenom treatment earlier. 2. Patients who had previous history of eczema, urticaria, drug or food allergies. 3. Patients who admit with well established envenoming signs

Design outcomes

Primary

MeasureTime frame
Number of reactions [From the time of antivenom administration]—

Secondary

MeasureTime frame
Severity of reactions [From the time of antivenom administration]—

Countries

Sri Lanka

Contacts

Public ContactProf SAM Kularatne

Professor in Medicine

samkul@sltnet.lk0094 773 420771

Outcome results

None listed

Source: SLCTR (via WHO ICTRP) · Data processed: Aug 9, 2026