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Comparison of two antibiotics in the treatment of typhoid fever in children in General Hospital, Vavuniya

Treatment of children with Typhoid fever: a comparative trial of Cotrimoxazole and Ampicillin in General Hospital Vavuniya.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
SLCTR
Registry ID
SLCTR/2010/001
Enrollment
Unknown
Registered
2010-01-22
Start date
2009-12-12
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Typhoid fever

Interventions

This is an interventional study where typhoid cases and controls will be selected from patients admitted to the paediatric ward within the age group of 6 years to 12 years. Randomization will be done

Sponsors

GH Vavuniya
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All clinically suspected patients with Typhoid fever

Exclusion criteria

Exclusion criteria: 1. Extremely unwell patients who are unable to tolerate oral fluids 2. Patients with complications of Typhoid fever such as intestinal hemorrhage, intestinal perforation or paralytic ileus 3. Known allergy to ampicillin or cotrimoxazole

Design outcomes

Primary

MeasureTime frame
The primary outcome measure will be the duration taken for the complete resolution of fever which is considered as maintaining normal body temperature for 48 hours or more, Development of adverse effects and disease related complications such as intestinal perforation, perforation or paralytic ileus will be assessed as secondary outcome measures [Day of fever free for 48 hours]—

Secondary

MeasureTime frame
1. Development of adverse effects to antibiotics 2. Development of disease related complications [Daily assessment]—

Countries

Sri Lanka

Contacts

Public ContactDr V. Kiridana

Consultant Paediatrician

vkiridana@yahoo.co.uk

Outcome results

None listed

Source: SLCTR (via WHO ICTRP) · Data processed: Aug 9, 2026