Acute paraquat intoxication
Conditions
Interventions
Apart from the standard management (Fernando, 1998), patients will be given intra venous vitamin C as follow, 100 mg, 500 mg, 1000 mg, 3000 mg/day and 3000 mg/ 8 h for 5 consecutive days. S. Y. Hong e
p<0.05, from 27.0 ± 3.8 IU to 22.0 ± 2.7 IU
p<0.01 and from 99.5 ± 3.4 mmHg to 87.3 ± 7.1 mmHg
p<0.001 respectively) during the observation period after administration of Intravenous vitamin C. They also noted that when the amount of vitamin C increased to 3000 mg, patients complained pain arou
L F Prescott, 1979) But rashes and anaphylaxis are known adverse effects of N-acetylcysteine with the dose given in paracetamol poisoning. Therefore I would like to propose a regimen for NAC which can
Initially 20 mg/kg in 200mL of 5% dextrose over 15 minutes Followed by 50 mg/kg in 500mL over 12 hours (? 4 mg/h/kg) twice per day for 3 days The total dose will be 320 mg/kg in 72 hours
Sponsors
South Asian Clinical Toxicology Research Collaboration
Eligibility
Inclusion criteria
Inclusion criteria: Consecutive patients who get admitted to General Hospital, Matara following history of acute exposure to paraquat and symptoms suggestive of acute exposure to paraquat will be selected for the study
Exclusion criteria
Exclusion criteria: • Unconscious patients • Pregnant mothers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of total antioxidant status in plasma after administration of Intra Venous vitamin C+placebo or vitamin C + NAC [First five consecutive days of acute exposure to paraquat ] | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of survival [Two months after acute exposure to paraquat ] | — |
Countries
Sri Lanka
Contacts
Public ContactDr Sudheera Jayasinghe
Probationary Lecturer
Outcome results
None listed