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The efficacy of letrozole compared to clomifene in induction and augmentation of ovulation in infertility

A study on anti-eostrogen clomifene citrate and aromatase inhibitor letrozole in induction of ovulation, in WHO group II anovulatory subjects, and in augmentation of ovulation in ovulatory infertility

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
SLCTR
Registry ID
SLCTR/2008/015
Enrollment
Unknown
Registered
2008-07-18
Start date
2008-08-15
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anovulatory and unexplained infertility

Interventions

In phase one: ovulation induction with clomifene citrate followed by letrozole in patients with anovulatory infertility In phase two: Subjects with unexplained infertility would undergo augmentation o

Sponsors

None
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Phase I: participants with WHO group II anovulatory infertility Phase II: Participants with unexplained infertility

Exclusion criteria

Exclusion criteria: 1. Previous ovarian surgery 2. Endocrinopathies (other than PCOS) giving rise to anovulation

Design outcomes

Primary

MeasureTime frame
Phase 1: Ovulation rate, endometrial characteristics Phase 2: Monofolicle development rate, endometrial characteristics []—

Secondary

MeasureTime frame
Follicular phase and luteal phase endocrinological changes []—

Countries

Sri Lanka

Contacts

Public ContactDr. Thilina S Palihawadana

Lecturer, Department of Obstetrics and Gynaecology

palihawadana_t@sltnet.lk

Outcome results

None listed

Source: SLCTR (via WHO ICTRP) · Data processed: Aug 9, 2026