Chronic Obstructive Pulmonary Disease (COPD)
Conditions
Interventions
Group 0: healthy patients. Each participant will carry out pre and post bronchodilator spirometry for COPD diagnosis by spirometric criteria. Sputum induction will make each participant, after making
Sponsors
Fundacion Neumologica Colombiana (FNC)
Universidad de la Sabana Bogota
Eligibility
Sex/Gender
Female
Age
40 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients with COPD defined by spirometric criteria diagnostic of GOLD 2. Exposure to smoke by cigarrette with package / year indice greater than 10 P / A 3. Exposure to wood smoke for over 10 years 4. Age older than 40 and younger than 90 years 5. Acceptance of the informed consent
Exclusion criteria
Exclusion criteria: 1. Medical history of lung diseases such as history of asthma, cystic fibrosis, tuberculosis, bronchiectasis 2. Presence of lower respiratory tract infection in the four weeks prior to sampling. 3. History of exacerbation of the disease in the four weeks prior to sampling. 4. Patients with severe COPD according to GOLD classification 5. Immunosuppression by comorbidities (autoimmune disease, cancer, chronic use of corticosteroids, HIV infection). 6. Simultaneous exposure to wood smoke and smoking. 7. Inability to perform spirometry 8. Inability sampling induced sputum 9. No acceptance of the informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Smoker (over 10 packets/year: dichotomic). Measuring time: at baseline Cooking with wood (more than 10 years of exposure in enclosed: dichotomic). Measuring time: at baseline Hospitalizations for COPD (no earlier than 8 weeks: dichotomi c). Measuring time: at baseline Using long-acting anti cholinergic (dichotomic). Measuring time: at baseline Use of short-acting anti cholinergic (dichotomic). Measuring time: at baseline Use of systemic steroids (dichotomic). Measuring time: at baseline Use of local steroids (dichotomic). Measuring time: at baseline Statin use (dichotomic). Measuring time: at baseline Spirometric parameter FEV1 / FVC ratio less than 0.70 (interval). Measuring time: at baseline Bronchodilator spirometry FEV1% predicted parameter (interval). Measuring time: at baseline Levels of IL-8 pg/ml (quantitative). Measuring time: after completing the sputum sampling in all subjects VEGF levels pg/ml (quantitative). Measuring time: after completing the sputum sampling in all subjects MMP-9 ng/ml (quantitative). Measuring time: after completing the sputum sampling in all subjects CC16 levels pg/ml (quantitative). Measuring time: after completing the sputum sampling in all subjects Levels of CCL-5 pg/ml (quantitative). Measuring time: after completing the sputum sampling in all subjects | — |
Secondary
| Measure | Time frame |
|---|---|
| Age (quantitative: completed years). Measuring time: at baseline Hometown (qualitative: rural urban). Measuring time: at baseline Marital status (qualitative: single-married-union freely widower separately). Measuring time: at baseline Coexists (nominal: with single-family). Measuring time: at baseline Schooling (ordinal: primary-university-technological-no). Measuring time: at baseline Social security (nominal qualitative: subsidized-contributory-other). Measuring time: at baseline | — |
Countries
Colombia
Contacts
Public ContactAngela Giraldo Montoya
Fundacion Neumologica Colombiana
Outcome results
None listed