Coronary artery disease
Conditions
Interventions
Study Group 1 (Multimodal anesthetic method): + General Anesthesia Intrathecal administration of opioids General anesthesia. Fentanyl induction with 5 mg / kg body weight + midazolam 0.2 mg / kg body
Sponsors
Surgical-Clinic Hermanos Ameijeiras Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Without previous cardiac surgery. 2.Ejection fraction >45 % without need of intra-aortic balloon pump support. 3.Without dysrhythmias. 4.Consciousness-awake and alert and without neurologic deficiency. 5.Urine output >0.5ml/kg and creatinine under 132 mmol/l. 6.Normal chest x-ray findings.
Exclusion criteria
Exclusion criteria: 1.No consent. 2.Absolute contraindication of regional anesthesia. 3.Acute (less than 7 days of evolutions) or recent (less than 30 days) myocardial infarction. 4.Used of inotropic drug. 5.Sings of heart failure. 6.Middle or severe Lung Hypertension. 7.Chronic obstructive lung disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative analgesia (Pain intensity using a Visual Analog Scale). Measurement time: 1 hour (h), 2h , 3h, 4h, 12h, 24h, 48h and 72h after the extubation of the patient. Total doses of morphine used in the postoperative period (mg).Measurement time: At leave to the postoperative intensive care unit. Time to extubation (Hours between the end of the surgery and the extubation of the patient). | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative analgesia (Hemodynamic changes in mean arterial blood pressure and heart rate during the incision of the skin, sternotomy and pericardiotomy). Measurement time: At the end of surgery Total doses of fentanyl used in the period (in micrograms). Measurement time: At the end of surgery. Adverse Events related to Opioid treatment (Yes/No). Measurement time: every 24 hour until hospital discharge. Perioperative complications (Yes/No). Measurement time: each 24 hour until hospital discharge. Complications associated with the use of regional anesthesia (Yes/No). Measurement time: every 24 hour until hospital discharge. Cost in the Intensive Care Unit (ICU). Measurement time: At leave the ICU ICU cost per day: Cost of a bed day per patient in ICU. Value used by the Economic department of the clinical site, 700 CUC per day). Cost in the hospital stay (including the days between ICU dischage until hospital discharge). Measurement time: At hospital discharge. The hospital stay cost per day: cost per day per patient from a bed in room. Value used by the Economic department of the clinical site, 350 CUC per day). | — |
Countries
Cuba
Contacts
Public ContactRosa Jimenez-Paneque
Surgical- Clinic Hermanos Ameijeiras Hospital
Outcome results
None listed