Candida
Conditions
Interventions
The sample of this study involved patients using conventional upper complete denture with denture stomatitis on the palatal denture-bearing mucosa, attended in the Prosthodontics Clinic of the Bauru S
D02.078.370.141.100
Sponsors
Karin Hermana Neppelenbroek
Faculdade de Odontologia de Bauru - Universidade de São Paulo
Eligibility
Inclusion criteria
Inclusion criteria: Volunteer users of conventional removable upper denture; clinical diagnosis for denture stomatitis in the palatal mucosa supporting the complete denture, both genders, any age, regardless of the condition of the mandibular arch and the use and status of the lower denture.
Exclusion criteria
Exclusion criteria: Volunteers with anemia; immunocompromised; with uncontrolled endocrinopathologies; in a therapeutic regimen with antibiotics, steroids or antifungals in the last three months; under antineoplastic treatment by radio or chemotherapy; users of the same upper complete denture for over 30 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome 1: Reduction of mycelial forms of Candida species both on the palatal mucosa affected by denture stomatitis and on the inner surface of the upper complete denture, verified by cytological examinations by smears obtained from these areas, from the observation, at the end of the treatment (14 days) and at the end of the experimental period (60 days of treatment discontinuation), of at least a 30% improvement in palatal smears as well as a large (greater or equal to 0.8) or very large (greater or equal to 1.20) effect size of treatment on the prosthetic smears.;Primary outcome 2: Reduction in the values of colony forming units per milliliter of Candida species both on the palatal mucosa affected by denture stomatitis and on the inner surface of the upper complete denture, verified by means of quantitative mycological cultures, from the observation, at the end of the treatment (14 days) and at the end of the experimental period (60 days of suspension of the treatment) of a large (greater or equal to 0.8) or very large (greater or equal to 1.20) effect size of treatment in cultures of both palate and prosthesis areas. ;Primary outcome 3: Reduction of clinical severity of denture stomatitis, verified by means of standardized photographs of the palatal mucosa affected by the lesion, from the observation, at the end of treatment (14 days) and at the end of the experimental period (60 days after suspension of treatment), of a large (greater or equal to 0.8) or very large (greater or equal to 1.20) effect size of the treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome 1: Assess whether the main general and local factors associated with Candida proliferation (patient's age and sex, age and nighttime use of current dentures, smoking, the type of denture stomatitis according to Newton, the use of xerostomia-inducing drugs, presence of xerostomia and poor oral and prosthesis hygiene habits) were present in most volunteers, through anamnesis, clinical examination and examination of the prosthesis, to verify their influence as predisposing factors to denture stomatitis. | — |
Countries
Brazil
Contacts
Public ContactKarin Neppelenbroek
Faculdade de Odontologia de Bauru - Universidade de São Paulo
Outcome results
None listed