Endothelial function Hypertension
Conditions
Interventions
The sample size for the development of the study was set at n = 81 patients with hypertension that will be randomly drawn into three exercise groups. After the enrollment of individuals in groups, the
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Sponsors
Instituto de Cardiologia - Fundação Universitária de Cardiologia/ ICFUC
Coordenação de Aperfeiçoamento de Nível Superior
Eligibility
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients aged between 18 and 75 years; diagnosed with hypertension; not participate in any kind of systematic physical activity; be ranked among insufficiently active, as IPAQ; signing the consent form; not present hyperreactivity during the test the physical tests (SBP> 220 mmHg and / or increase of more than 15 mmHg for DBP); not febrile and / or infectious disease state, as well as diabetes mellitus; not class II obesity or more 35 kg / m2; not present heart failure class III or IV; recent cardiovascular event in the last three months; chronic renal failure; history of malignant disease with a life expectancy <2 years; not be active smoker and not present alcoholism; not have orthopedic impairments or any physical or mental limitation that prevents the performance of physical exercises.
Exclusion criteria
Exclusion criteria: Patients outside the age range of 18 to 75 years; without diagnosis of hypertension; be participating in some kind of systematic physical activity; not sign the Instrument of Consent; hyperreactivity present during the test the physical tests, presenting fever and / or infectious disease as well as diabetes mellitus; class II obesity or having more than 35 kg / m2; present heart failure class III or IV; cardiovascular event in the last 3 months; chronic renal failure; history of malignant disease with a life expectancy <2 years; be active smoker and present alcoholism, have orthopedic impairments or any physical or mental limitation that prevents the performance of physical exercises; will still be excluded from the sample individuals who have not obtained attendance to 85% of the number of training or miss more than two consecutive workouts.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improved endothelial function, determined by flow-mediated brachial artery (FMD), using an ultrasound (with software for vascular-dimensional images (2D) color and spectral Doppler with an internal monitor electrocardiogram (ECG) and a vascular high frequency transducer. the coefficient of variation expected between images is 1.8 to 5%. the dependent vasodilation flow are expressed as percentage change in diameter of the brachial, and the expected normal values 10-20% in pre and post intervention 12 weeks of aerobic training, resistance and combined measurements (aerobic + resistance). | — |
Secondary
| Measure | Time frame |
|---|---|
| - Reduced Blood Pressure measured by ambulatory blood pressure monitoring (ABPM) 4 mmHg for systolic and 2 mmHg for diastolic blood pressure, using the Dina-Map+ branded device +, oscilométriconas method in pre measurements and after 12 intervention weeks of exercise training, weathered and combined (aerobic + resistance). - Improvement in plasma levels of total cholesterol, HDL, LDL and triglycerides and fasting glucose, measured by biochemical tests 10% pre and post intervention. - Improvement in functional capacity, measured by maximum oxygen uptake (VO2max), from 10% pre and post intervention 12 weeks of aerobic training, resistance and combined (aerobic + resistance). - Increased maximum dynamic strength and muscular endurance as measured by the maximum repetition test 10% pre and post intervention 12 weeks of aerobic training, resistance and combined (aerobic + resistance). | — |
Countries
Brazil
Contacts
Public ContactAlexandre Lehnen
Instituto de Cardiologia - Fundação Universitária de Cardiologia/ ICFUC
Outcome results
None listed