HTLV I Associated Myelopathy
Conditions
Interventions
This is an interventional study, characterized by Galvanic Vestibular Stimulation, as a new therapeutic strategy for balance rehabilitation. 150 individuals will be invited to participate in the resea
E05.723.402
Sponsors
Universidade Federal de Minas Gerais
Fundação de Amparo à Pesquisa do Estado de Minas Gerais
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Control group: Composed of individuals with negative serology for HTLV-1 by the ELISA (Enzyme-linked-immunosorbent -assay) test; Group with HTLV-1 infection: Composed of former blood donors from Fundação Hemominas with seropositivity defined by the ELISA test and confirmed through WB (Western Blot) or molecular tests (Polymerase Chain Reaction - PCR); HAM group: individuals with sufficient clinical signs, according to the criteria proposed by the adapted WHO (GRASSI et al, 2011; CASTRO-COSTA, 2006), classified according to the adapted Expanded Functional Disability Scale (EDSS) and OSAME presenting classification from two on both scales.
Exclusion criteria
Exclusion criteria: Positive serology for human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), positive Venereal Disease Research Laboratory (VDRL) test; History of stroke and epilepsy ; Inability to remain in the examination position; Recurrent episodes of vertigo or history of previously diagnosed peripheral vestibulopathy; Patients with a pacemaker or any device that may undergo changes resulting from the use of EVG; Cognitive changes justified by some other pathology associated with Parkinson's disease; Individuals who are alienated and unable to answer for their own actions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to find an improvement in postural balance, verified through the Berg Balance Scale evaluation method, based on the observation of an increase in the score, in which results above or equal to 45 are satisfactory after intervention; Using the Time up and go test method, we will observe a decrease in the post-intervention score, in which values below 10 or between 10 and 19 are acceptable parameters as they configure values for independent individuals with a good balance; It is expected to verify, using the computerized posturography method, an increase in the stability limit comparing pre and post intervention values and an increase in the values of visual, somatosensory, vestibular and general balance indexes reaching values above 90%, compatible with values of reference of elderly individuals without the pathology. ;It is expected to find an improvement in voluntary attention, verified through the method of comparing the results of the P300 exam, based on the observation of a decrease in latency and an increase in wave amplitude of at least 30 ms and 5 µV, respectively, pre and post -intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcomes are expected. | — |
Countries
Brazil
Contacts
Public ContactLudimila Labanca
Universidade Federal de Minas Gerais
Outcome results
None listed