Pulpitis
Conditions
Interventions
Control group: 50 vital pulp teeth will receive endodontic treatment. Experimental group 1: 360 teeth, including teeth with irreversible pulpitis (72 teeth), endo-perio lesion with necrotic pulp (72 t
Procedure/surgery
E06.397
Sponsors
Faculdade de Odontologia de Piraicaba-Universidade Estadual de Campinas
Faculdade de Odontologia de Piraicaba-Universidade Estadual de Campinas
Eligibility
Inclusion criteria
Inclusion criteria: Patients with systemic health condition ASA I or II. Permanent teeth with pulp necrosis; pulp vitality; pulpitis; endo-perio lesions; endodontic treatment failure; periapical lesion; periodontal tissues.
Exclusion criteria
Exclusion criteria: use of antifungals; antibiotics; immunosuppressants; and antivirals (up to 3 months previously to the study); and teeth with root fracture.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The endodontic microbiota and its virulence factors are expected to be evaluated using Nested-PCR, Checkerboard, next-generation sequencing, PCR, LPS, and LTA methods. We will observe if there was a decrease in the microorganisms and their virulence factors after the several stages of the endodontic treatment/retreatment/surgery.;It is expected to identify the host immune response using ELISA. We will observe the host immune response to infection and after the various stages of endodontic treatment/retreatment/surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcomes are expected. | — |
Countries
Brazil
Contacts
Public ContactBrenda Gomes
Faculdade de Odontologia de Piracicaba-Universidade Estadual de Campinas
Outcome results
None listed