Children with acyanogenic congenital heart defects operated for total correction
Conditions
Interventions
The children were randomized into two groups of 25 patients:
Group A - 25 patients.
Solution for myocardial protection: Histidine-Tryptophan-Ketoglutarate (HTK), frozen (about 5 ° C), given as a si
2. Serum dosage of cardiac enzymes: troponin and creatine kinase-MB / CK-MB (collected preoperatively at the end of surgery and 6, 12, 18, 24 and 48 hours after surgery)
3. Calculation of the inotropic score (VIS) by type and amount of vasoactive drugs used every two hours, in the first 36 hours after surgery.
Group B - 25 patients.
Solution for myocardial protectio
3. Calculation of the inotropic score (VIS) by type and amount of vasoactive drugs used every two hours, in the first 36 hours after surgery.
Drug
Procedure/surgery
Other
C14.280
Sponsors
Hospital do Coração de Messejana Dr. Carlos Alberto Studart Gomes
Hospital do Coração de Messejana Dr. Carlos Alberto Studart Gomes
Eligibility
Age
1 Days to 215 Months
Inclusion criteria
Inclusion criteria: Children with acyanotic congenital cardiopathies submitted to corrective surgery with extracorporeal circulation and aortic clamping and volunteers to participate in the study.
Exclusion criteria
Exclusion criteria: Children operated for correction of atrial septal defect exclusively, reoperations, palliative surgeries, emergency surgeries, negative in participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome - Homogeneity between the two groups After analysis of the sample amplitude distribution, mean and standard deviation (SD)of age, weight and time of CPB, surgery and aortic clamping, according to the groups, no statistical difference was evidenced for any of these variables.;Expected outcome - Similar behavior over time of analyzed variables between Groups; Method - Comparative analysis of the estimated marginal means; Regarding the behavior of the troponin, CK-MB, VIS and ETT variables, all of them varied significantly in time (all p <0.001) but with no difference between the solutions, that is, between Groups. Troponin curve between groups - p = 0.997 CK-MB curve between groups - p = 0.693 VIS curve between groups - p = 0.449 Shortening curve VE - p = 0.319 | — |
Secondary
| Measure | Time frame |
|---|---|
| A total of 6 (12.0%) patients required cardiopulmonary defibrillation / cardioversion after ECC (p = 0.384), 01 (2.0%) required ECPD (p = 0.312) and 01 (2.0%) to death (p = 0.312). There was no statistical difference between groups for any of these variables. | — |
Countries
Brazil
Contacts
Public ContactAcrisio Valente
Hospital do Coração de Messejana Dr. Carlos Alberto Studart Gomes
Outcome results
None listed