Migraine with aura [classical migraine]
Conditions
Interventions
living conditions and habits
inventory pharmacological
physical examination with vital data
complete neurological examination
POPULATION AND INTERVENTION: Patients treated from two sources will be invited to participate in the study: (1) Outpatient clinic Neurology, Hospital de Clínicas, UFPR
and (2) private offices for employees. Three groups will be recruited: patients with migraine episodic, patients with chronic migraine and control. Since CM cases are less frequent than their non-chro
presence of prodromal and post-dermal symptoms (defined as different headache symptoms occurring up to 72 h before or after the pain crisis)
morbid history and factors comorbid with migraine
family history (up to 2nd grade)
and complementary exams according to clinical judgment. The degree of disability with migraine will be assessed through the Migraine Disability Assessment (MIDAS) (FRAGOSO, 2002). The tool for analysi
Genetics
Other
Sponsors
Hospital de Clinicas da Universidade Federal do Paraná.
Hospital de Clinicas da Universidade Federal do Paraná.
Eligibility
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Will be included individuals who meet the diagnostic criteria for migraine without aura, migraine with aura and / or chronic migraine associated or not with abuse of analgesics; are between 18 and 65 years of age at the time of inclusion; accept to participate in the study on a voluntary basis. The control group will include people who do not suffer from headache and for that, they should answer negatively to the question: "Have you ever suffered from frequent headaches and without an obvious cause?". Patients with complaints other than headache will be invited, employees of recruiting institutions, escorts of patients with no familiarity with the study group, volunteers recruited from disclosure by verbal approach or physical media and electronic.
Exclusion criteria
Exclusion criteria: Will be excluded from the study individuals who do not complete all applied scales; present other types of headache concomitantly, such as trigeminal neuralgia and secondary headaches; withdraw the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate the proportion of polymorphisms in genes related to SAM using methods of comparison of quantitative and qualitative variables seeking to observe differences between the 3 groups evaluated: episodic migraine, chronic migraine and control. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate the frequency of specific signs and symptoms using methods of comparing quantitative and qualitative variables seeking to observe differences between the 3 groups evaluated: episodic migraine, chronic migraine and control.;Evaluate the proportion of patients with known factors of chronification by means of comparison methods of quantitative and qualitative variables seeking to observe differences between the 3 groups evaluated: episodic migraine, chronic migraine and control.;Evaluate the proportion of analgesic abuse using methods of comparison of quantitative and qualitative variables seeking to observe differences between the 3 groups evaluated: episodic migraine, chronic migraine and control.;Evaluate the frequency of “dopaminergic” symptoms (such as yawning) using methods of comparing quantitative and qualitative variables seeking to observe differences between the 3 groups evaluated: episodic migraine, chronic migraine and control.;Evaluate the proportion of refractory cases using methods of comparing quantitative and qualitative variables seeking to observe differences between the 3 groups evaluated: episodic migraine, chronic migraine and control. ;Evaluate the proportion of comorbidities using methods of comparing quantitative and qualitative variables seeking to observe differences between the 3 groups evaluated: episodic migraine, chronic migraine and control. | — |
Countries
Brazil
Contacts
Public ContactElcio Piovesan
Hospital de Clinicas da Universidade Federal do Paraná.
Outcome results
None listed