Autism Spectrum Disorder Proteome
Conditions
Interventions
This is a prospective observational cohort study whose overall objective is to identify the proteomic profile of saliva in patients diagnosed with Autism Spectrum Disorder, correlating it with the dif
to assess whether there are differences in the salivary proteomic profile according to each level of support
to assess whether there are differences in the proteomic profile between adults and children within each level of support
correlate changes in the salivary proteomic profile with oral changes observed in patients according to each level of support
and, using a validated tool, assess the perceived levels of stress and burden among the primary caregivers of the patients included in the sample. Saliva will be collected using an aspiration device,
10 patients aged 18 to 30 years. Total of 20 patients. Group 2 (support level 2): 10 patients aged 5 to 18 years
10 patients aged 18 to 30 years. Total of 20 patients. Group 3 (Level 3 support): 10 patients aged 5 to 18 years
10 patients aged 18 to 30 years. Total of 20 pat
Sponsors
Universidade de São Paulo
Universidade de São Paulo
Eligibility
Age
5 Years to 30 Years
Inclusion criteria
Inclusion criteria: Individuals with a confirmed diagnosis of Autism Spectrum Disorder across the three different levels of support collaborative care, care provided at the Specialty Clinic for Patients with Special Needs at the Barradas Medical Specialty Clinic; aged 5 to 30 years
Exclusion criteria
Exclusion criteria: Patients with Autism Spectrum Disorder classified as non-cooperative; patients with systemic conditions of inflammatory and autoimmune origin; patients complaining of dry mouth
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We expect to find differences in the salivary proteomic profile of patients with Autism Spectrum Disorder, as determined by salivary analysis, compared to those without a diagnosis of the disorder.;It is hoped that, by analyzing the salivary proteomic profile, potential salivary biomarkers will be identified that can aid in assessing compatibility with the level of support, treatment options, and, eventually, diagnostic and therapeutic strategies for this patient population.;Based on the protein changes identified across different patient profiles and levels of care, it is hoped that we will be able to determine whether there is an increased susceptibility to changes in oral health | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected that direct caregivers of patients with Autism Spectrum Disorder will experience high levels of burnout and job satisfaction. | — |
Countries
BR
Contacts
Public ContactIsis Ghelardi
Universidade de São Paulo
Outcome results
None listed