Breathing exercises for people with sickle cell disease

Evaluation of the use of breathing exercises in patients with sickle cell disease

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-9vtywnp

Enrollment

Registered

2026-07-24

Start date

2021-09-29

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise tolerance

Interventions

This is an open-label, two-arm, randomized controlled clinical trial, with allocation of participants to an intervention group (IG) and a control group (CG). Thirty clinically stable adult participant

however, participants in both groups were contacted weekly by voice call or text message, with the objective of balancing the attention received from the researchers and reducing the risk of attention

Eligibility

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Diagnosis of sickle cell disease; both sexes; aged over 18 years and under 70 years; clinically stable at the time of the assessments and intervention; availability to attend the study site in person on the scheduled assessment dates; use of a smartphone and messaging application by the participant or companion to record and send videos of the breathing exercise to the researchers.

Exclusion criteria

Exclusion criteria: Cardiac, pulmonary, or musculoskeletal disease not resulting from the progression of sickle cell disease; neurological diseases or sequelae that prevent the adequate performance of the proposed assessments or intervention; hip osteonecrosis associated with difficulty walking due to severe or acute pain.

Design outcomes

Primary

Measure	Time frame
Change in inspiratory muscle strength, assessed by maximal inspiratory pressure (MIP), after 12 weeks of diaphragmatic breathing intervention, compared with the control group.	—

Secondary

Measure	Time frame
Changes in volumetric capnography parameters; in spirometric parameters; in exercise tolerance; in the degree of mobility-related dyspnea; and in the ability to perform activities of daily living after 12 weeks of diaphragmatic breathing intervention, compared with the control group.	—

Countries

Contacts

Public ContactFábio Galvão

Centro de Hematologia e Hemoterapia - HEMOCENTRO

prof.fabiogalvao@yahoo.com.br+55 19 35218383

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Aug 10, 2026