Attention
Conditions
Interventions
This study is a randomized, controlled, double-blind clinical trial. One hundred students will be randomly assigned to two groups. The active group (n=50) will be instructed to consume one daily servi
G07.203.300.456
Sponsors
Sociedade de Educação Superior e Cultura Brasil S.A.
Sociedade de Educação Superior e Cultura Brasil S.A.
Eligibility
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: Healthy UNISUL medical students who do not have any diagnosed and/or treated disease
Exclusion criteria
Exclusion criteria: Students who already use supplements; have liver or kidney damage; use illicit drugs; any medication with a depressant effect on the central nervous system; students with immunosuppressive diseases; oncological diseases; infectious diseases or in a feverish state; epileptic diseases; with a diagnosis of depression; pregnant and/or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to find the difference in cognitive performance parameters, with recording of event-related potentials (ERP), such as reaction time to target and non-target stimuli, omission and commission errors in target and non-target stimuli and discrimination time, in the basal period, 1, 7 and 30 days of supplementation | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected to observe the attentional performance assessed through the Psychological Battery for Attention Assessment, in the active group in relation to the control group at the beginning and at the end of the study;It is expected to find the cognition using the Montreal Cognitive Assessment (MoCA) scale for mild cognitive impairment (MCI) at baseline and end of the study;It is expected to observe the prefrontal cortex activity by analyzing cerebral blood flow at the beginning and end of the study;It is expected to find the activity of the autonomic nervous system by analyzing heart rate variability at the beginning and end of the study;It is expected to observe the body composition through bioimpedance analysis at the beginning and end of the study;It is expected to find difference in the brain plasticity by measuring serum concentrations of Brain-Derived Neurotrophic Factor (BDNF) at baseline and end of the study;It is expected to observe difference in the oxidative stress parameters by measuring serum concentrations of 2',7' dichlorofluorescein (DCF), and the activity of the enzymes catalase (CAT) and superoxide dismutase (SOD), at the beginning and end of the study;It is expected to find difference in the mitochondrial function by measuring the citrate synthase enzyme and the activity of Complex I and II of the electron transport chain, at the beginning and end of the study | — |
Countries
Brazil
Contacts
Public ContactDaniel Martins
Universidade do Sul de Santa Catarina
Outcome results
None listed