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Interaction between genes of inflammatory mediators and the effects of physical exercise in older women

Interaction between single nucleotide polymorphisms of the genes of TNF-alpha, IL6, IL10 and brain-derived neurotrophic factor (BDNF) and the effects of physical exercise in older women

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-9v9cwf
Enrollment
Unknown
Registered
2012-01-09
Start date
2011-11-03
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aging,inflammation, exercise, sarcopenia

Interventions

Two training protocols: Group 1: muscle strength training of the lower limbs at 75% of 1 maximal resistance, 3 times per week for 10 weeks. Group 2: aerobic training of 5 minutes warm up, 40 minutes o
other
E02.779.483

Sponsors

Universidade Federal de Minas Gerais
Lead Sponsor
Escola de Educação Física, Fisioterapia e Terapia Ocupacional - UFMG
Collaborator

Eligibility

Sex/Gender
Female
Age
65 Years to 99 Years

Inclusion criteria

Inclusion criteria: Women above the age of 65; community-dwelling

Exclusion criteria

Exclusion criteria: Elderly people with cognitive impairment detectable by the Mini Mental State Examination, acute phase inflammatory disease, tumor growth in the last five years, current use of immunomodulating medications, amputation or lower limb fracture in the last 6 months, presence of any neurological disease and current participation in an alternative exercise programme.

Design outcomes

Primary

MeasureTime frame
Plasma levels: interleukin-6 (IL-6), interleukin-10 (IL-10), soluble tumor necrosis factor alpha receptor-1 (sTNFR1), soluble tumor necrosis factor alpha receptor-2 (sTNFR2), Brain-Derived Neurotrophic Factor (BDNF) measured by ELISA method.;Functional capacity: timed up and go, Sit-to-stand test, 10-Meter Wlak Test;Single nucleotide polymorphism (SNP): TNF-alpha (rs1800629); IL6 (rs1800795), IL10 (rs1800896), BDNF (rs6265 and rs4923463)—

Secondary

MeasureTime frame
Muscle strength: strength of the muscles in the knee joint measured by Biodex System 3 Pro ® isokinetic dynamometer (Biodex Medical Systems Inc., Shirley, NY, USA); hand grip, by JAMAR dynamometer (PC5030JI);Aerobic capacity: Six-Minute Walk Test (distance); Shuttle Walking Test (distance).;Allostatic load: by waist-hip ratio,salivary cortisol concentrations, Perceived Stress Scale, plasma levels of IL-6 and soluble tumor necrosis factor alpha receptor-1 (sTNFR1).;Depressive symptoms: Geriatric depression scale—

Countries

Brazil

Contacts

Public ContactLeani Pereira

Escola de Educação Física, Fisioterapia e Terapia Ocupacional - UFMG

leanismp.bh@terra.com.br31-3409-7410

Outcome results

None listed

Source: REBEC (via WHO ICTRP)