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Evaluation of genetic changes, organism imbalance and gene expression in patients with Amyotrophic Lateral Sclerosis (ALS)

Evaluation of genetic alterations, oxidative stress and gene expression in patients with Amyotrophic Lateral Sclerosis (ALS) - Amyotrophic Lateral Sclerosis (ALS) Amyotrophic Lateral Sclerosis (ALS)

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
REBEC
Registry ID
RBR-9tt23hz
Enrollment
Unknown
Registered
2021-09-30
Start date
2015-05-10
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amyotrophic lateral sclerosis

Interventions

A sample of blood and material from the oral cavity will be collected from 30 patients with ALS and 30 healthy controls, all over 18 years of age. ALS patients will be recruited at the Neuromuscular D

Sponsors

Faculade de Medina de Botucatu - UNESP
Lead Sponsor
Universidade Federal do Amapá
Collaborator

Eligibility

Sex/Gender
Male
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: male, erectile dysfunction, stable affective relationship, fixed single partner, patients with premature ejaculation

Exclusion criteria

Exclusion criteria: anatomical genital deformities; erectile dysfunction secondary to spinal cord injury, concomitant diagnosis of other sexual dysfunctions , prolactin level greater than three times the upper limit, testosterone level less than 300, uncontrolled psychiatric disorder, decompensated diabetes mellitus, history of stroke, myocardial infarction, significant cardiovascular disease, poorly controlled arterial hypertension, history of important hematological, renal, hepatic abnormalities, abuse of illicit substances

Design outcomes

Primary

MeasureTime frame
It is expected that with the method used, participating patients present improvements in the evaluated indices, either the increase in the mean ejaculatory latency interval and/or the international index of erectile function.

Secondary

MeasureTime frame
Secondary outcomes are not expected

Countries

Brazil

Contacts

Public ContactLECILDO BATISTA
lecildolira@unifap.br+5596991794988

Outcome results

None listed

Source: REBEC (via WHO ICTRP)