Cardiovascular Diseases
Conditions
Interventions
This is a prospective cohort observational study. The study will investigate the joint association of movement behaviors (objectively measured sedentary behavior and physical activity) with the risk o
G11.427.410.698.277
Sponsors
Pós-Graduação em Educação Física da Universidade Federal do Rio Grande do Norte - Lagoa Nova Campus Central
Universidade Federal do Rio Grande do Norte
Eligibility
Age
80 Years to No maximum
Inclusion criteria
Inclusion criteria: Both genders; be 80 years or older; have no severe cognitive impairment, assessed by the MoCA (Montreal Cognitive Assessment); live in the community, i.e., not residing in a long-term care facility; be able to walk with or without assistive devices; be able to perform basic activities of daily living independently or with partial dependence, considering a Katz index score greater than 2
Exclusion criteria
Exclusion criteria: Uncontrolled blood pressure (above 160/105 mmHg); decompensated diabetes (fasting glucose above 250 mg/dL); severe language, hearing and/or vision impairments that may prevent participation in the study; history of recent cardiovascular events (less than six months); severe and/or unstable cardiovascular diseases (e.g., unstable angina, severe or uncontrolled arrhythmias, myocardial infarction, coronary artery disease, stroke, deep vein thrombosis, peripheral arterial disease, pacemaker use or heart failure); severe and limiting lung diseases (such as chronic obstructive pulmonary disease, pulmonary emphysema, chronic bronchitis or asthma); chronic kidney disease requiring dialysis; severe or serious neurological diseases (such as Parkinson's, multiple sclerosis or Alzheimer's); history of cancer with treatment in the last six months; signs or symptoms of any acute health condition and/or hospitalization in the last four weeks (e.g., flu, infection, virus); any medical contraindication to performing moderate to vigorous physical activity; refusal to sign the informed consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To monitor the occurrence of major adverse cardiovascular events, expecting to find a high incidence among individuals aged 80 years and over, verified through self-report in quarterly telephone interviews, based on confirmation of acute myocardial infarction, stroke, non-acute cardiac surgery (angioplasty or revascularization), or death from any cause;To verify the incidence of falls, expecting to find a moderate frequency of fall reports in this age group, through quarterly telephone interviews, based on the report of at least one fall in the period and collection of information on number, location, time, cause, circumstances, need for medical care, fractures, and hospitalizations | — |
Secondary
| Measure | Time frame |
|---|---|
| To estimate arterial stiffness, expecting to find elevated values in part of the participants due to vascular aging, through measurement of aortic pulse wave velocity (PWV) using the Dyna-Mapa AOP device, considering as parameters values above the 75th percentile for sex in the Brazilian population aged 70 years and over (=13.0 m/s for women; =12.1 m/s for men);To measure carotid intima-media thickness, expecting to observe increased thickness compatible with subclinical atherosclerosis, through high-resolution ultrasound, considering as parameters values above the 75th percentile for age, sex, and ethnicity, according to the Brazilian Society of Cardiology;To measure total cholesterol levels, expecting to find elevated levels in part of the participants, through fasting venous blood collection (8–12 hours) using an automated enzymatic colorimetric method, based on comparison with national reference values;To measure HDL cholesterol levels, expecting to identify reduced levels in part of the participants, through fasting venous blood collection (8–12 hours) using an automated enzymatic colorimetric method, based on comparison with national reference values;To measure fasting blood glucose, expecting to find elevated values in part of the participants due to the high prevalence of diabetes in the older population, through fasting venous blood collection (8–12 hours) using an enzymatic method, based on comparison with national reference values;To assess renal function, expecting to find alterations compatible with functional decline related to aging, through analysis of urine collected at home following recommendations of the Brazilian Society of Nephrology, based on verification of proteinuria and albuminuria according to reference values;To assess fear of falling, expecting to find moderate levels of concern about falling in this age group, through the FES-I questionnaire validated for the Brazilian older population, based on the total score obtained on the instrume | — |
Countries
Brazil
Contacts
Public ContactEduardo Costa
Universidade Federal do Rio Grande do Norte
Outcome results
None listed