Chronic kidney failure, kidney transplantation
Conditions
Interventions
Experimental groups: (1) 52 patients undergoing deceased-donor renal transplantation who will be given intraoperatively a balanced fluid solution with sodium, chloride, potassium and magnesium, pH equ
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Sponsors
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP
Eligibility
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients with chronic renal disease under hemodialysis, aged 18 to 65 years, both genders, physical status III and IV according to the American Society of Anesthesiologist (ASA)
Exclusion criteria
Exclusion criteria: Patients with preoperative hemoglobin less than 8 g/dL and those under peritoneal dialysis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delayed graft function (yes or no), verified by the need to perform hemodialysis up to 7 days after the transplantation. It is expected a 50% reduction (60% to 30%) in the incidence of delayed graft function with the administration of the balanced solution with pH equal to 7,4 (Plasma-Lyte), as compared to the 0,9% sodium chloride solution administration. | — |
Secondary
| Measure | Time frame |
|---|---|
| Acid-base balance modifications: pH, sodium bicarbonate and base excess values at the end of the transplant will be mesured. Values of sodium, potassium, chloride, calcium and magnesium at the end of the transplant will be mesured. Mean values of these variables will be compared by variance analysis. P < 0.05 will be considered significative. | — |
Countries
Brazil
Contacts
Public ContactPaulo do Nascimento Junior
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP
Outcome results
None listed