Tobacco use
Conditions
Interventions
Group 1 consisted of active smokers or former smokers for more than 10 years without spirometric diagnosis of chronic obstructive pulmonary disease
number of individuals in this group will be 16
The subjects will be submitted to an incremental test to the exercise tolerance limit by cardiopulmonary test in cycle ergometer. In this test, after 2 minutes of rest and 2 minutes of warm-up with mi
They will also be submitted to an incremental test to the tolerance limit by cardiopulmonary exercise test in cycle ergometer. Constant load tests will be performed on separate days, within one week,
Drug
D02.065.884.675
Sponsors
Universidade Federal de Mato Grosso do Sul
Hospital Universitário de Mato Grosso do Sul
Eligibility
Age
35 Years to 80 Years
Inclusion criteria
Inclusion criteria: Symptomatic vascular phenotype; Individuals of both sexes; Age between 35 and 80 years; History of smoking for more than 10 years; Sinus rhythm; Preserved left ventricular ejection fraction (higher than 50%); The evaluated patients should be able to perform spirometry, carbon monoxide diffusion test and cardiopulmonary exercise test.
Exclusion criteria
Exclusion criteria: Carrier of diabetes mellitus, bronchial asthma, previous myocardial infarction, heart failure, complex ventricular arrhythmias; Chronic atrial fibrillation; Body mass index lower than 18.5 or higher than 35 kg per m²; Anemia with hemoglobin lower than 11 g% in women and lower than 12 g% in men; Chronic hypoxemia of undetermined cause; neuromuscular, orthopedic or psychological limitation; Contraindication to the use of sildenafil citrate or previous use of it thereof.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the effect of sildenafil use on the cycle ergometer maximum exercise tolerance time. Considering a 2-by-2 cross-sectional design and a clinically important minimum difference of 100 seconds suggested for constant load tests at 75% of the maximum power in the incremental intervention test, it was calculated that 16 Group 1 individuals with the disease and 8 healthy individuals from Group 2 give the study 85% power with a 5% alpha. The level of statistical significance will be set at p less than 0.05. | — |
Secondary
| Measure | Time frame |
|---|---|
| Define a vascular phenotype in the smoker by clinical, functional criteria and imaging resources together. ;To evaluate the effects of sildenafil on the adjustment kinetics of oxygen consumption in the transition from rest to exercise in smokers with suspected microvascular disease. | — |
Countries
Brazil
Contacts
Public ContactLeandro Goelzer
Hospital Universitário de Mato Grosso do Sul
Outcome results
None listed