Post-Acute COVID-19 Syndrome
Conditions
Interventions
This is a longitudinal, prospective, randomised, open clinical study. Total patients included: 60 patients coming out of hospitalisation for severe COVID-19. Randomisation to group 1: 30 patients who
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Sponsors
Universidade Estadual de Campinas
Hospital de Clínicas da Universidade Estadual de Campinas
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients of both sexes; greater than or equal to 18 years old; diagnosis of severe COVID-19 who have been hospitalised; post-discharge outpatient assessment, have dyspnoea at rest; or a distance covered in the six-minute walk test of less than or equal to 400 metres and or 80% of that predicted using a predictive reference equation; or a drop in peripheral oxygen saturation of greater than or equal to 4 points
Exclusion criteria
Exclusion criteria: Osteoarticular or cognitive limitations; or patients with a tracheostomy; or patients with previous respiratory or cardiovascular diseases that prevent the participant from performing the proposed tests
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected Outcome 1: The study aims to observe an improvement in functional capacity, as measured by an increase of at least 50 metres in the distance covered during the six-minute walk test, between pre- and post-intervention;Outcome found 1:The six-minute walk test showed an increase of 164.5 metres in group 1 and 154.2 metres in group 2 between the pre- and post-intervention periods | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome 2: It is expected that there will be a significant improvement in the quality of life, as measured by the SF-36 survey, between pre- and post-intervention;Outcome found 2: There was a significant improvement in the quality of life, as evidenced by the scores of the physical and mental summary components of the SF-36 survey, between pre- and post-intervention;Expected outcome 3: The intervention is expected to improve functional capacity, as measured by the increase in distance walked in the six-minute walk test, between baseline and after six months of follow-up;Outcome found 3: There was an improvement in functional capacity between baseline and after six months of follow-up;Expected outcome 4: We expect to find a significant increase in respiratory muscle strength assessed by means of maximum respiratory pressures between the pre- and post-intervention periods;Outcome found 4: There was a significant improvement in respiratory muscle strength between pre- and post-intervention;Expected Outcome 5: A significant increase in respiratory muscle endurance, as assessed using the Powerbreathe KH2 equipment, is expected between the pre- and post-intervention periods;Outcome found 5: There was an improvement in respiratory muscle endurance between pre- and post-intervention;Expected outcome 6: We expected to find a significant increase in handgrip strength assessed using a hand-held dynamometer between pre- and post-intervention ;Outcome found 6: There was an improvement in handgrip strength between pre- and post-intervention | — |
Countries
Brazil
Contacts
Public ContactMônica Corso Pereira -faculdade de ciências médicas
Universidade Estadual de Campinas
Outcome results
None listed