cystic fibrosis
Conditions
Interventions
Therapeutic procedures include inhalation of two inhaled therapies, namely DNase and HSS, and the high frequency oral oscillation physiotherapy (OHFO) procedure. The study subjects will be divided int
Drug
Device
E02.779
Sponsors
Renata Maba Gonçalves
Hospital Infantil Joana de Gusmão
Eligibility
Age
6 Years to 14 Years
Inclusion criteria
Inclusion criteria: This study included children and adolescents with CF between 6 to 14 years of age, under regular follow-up at the CF outpatient clinic in the Joana de Gusmão Children's Hospital (HIJG) in Florianópolis/SC-Brazil. The diagnosis was confirmed by two altered sweat tests (chlorine greater than 60mEqs/l) and confirmed genetic alterations. All participants were clinically stable at the time of data collection, according to the application of specific clinical scores. To assure clinical stability and inclusion of the participants, the Cystic Fibrosis Clinical Score (CFCS) [18] and the Cystic Fibrosis Foundation Score (CFFS) [19] for pulmonary exacerbation were applied.
Exclusion criteria
Exclusion criteria: Individuals who exhibited infection or upper airway alterations (coryza, sneezing, obstruction of nose, rhinitis and epistaxis) and who were unable to perform any of the study procedures were excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the effect of inhalation therapy associated with respiratory physiotherapy on respiratory mechanics in children with cystic fibrosis, using the two main inhalation therapies already used by patients and evaluating with the Pulse Oscillometry System.;To evaluate the effect of inhalation therapy associated with respiratory physiotherapy on pulmonary function in children with cystic fibrosis, using the two main inhalation therapies already used by patients and evaluating with spirometry. | — |
Secondary
| Measure | Time frame |
|---|---|
| To verify the relationship of the IOS variables with age, BMI and cystic fibrosis severity classification data, the referred parameters will be collected and the relationship will be made by statistical analysis. | — |
Countries
Brazil
Contacts
Public ContactRenata Wamosy
Universidade do Estado de Santa Catarina
Outcome results
None listed