Actinic keratosis
Conditions
Interventions
experimental group: 18 patients with three to ten actinic keratoses by forearm will be evaluated clinically (keratoses count actinic and aging assessment of the forearms), biopsied, and receive topica
Drug
Other
Sponsors
Faculdade de Medicina de Botucatu - UNESP
Faculdade de Medicina de Botucatu - UNESP
Eligibility
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Age above 18 years of both sexes; provide at least three and no more than ten clinically compatible with actinic keratosis lesions on each forearm bilaterally.
Exclusion criteria
Exclusion criteria: Selected treatment area that has atypical clinical appearance or other extensive dermatoses forearms; current and previous clinical diagnosis or evidence of any medical condition that expose the patient to increased risk, interfere with the safety or efficacy of the proposed treatment; present hypersensitivity or allergy to any of the substances under study; use of topical or systemic immunosuppressive substance, oral retinoid, and other local treatments (eg corticosteroids, anti-inflammatories, retinoids); immunocompromised; pregnancy suspected or confirmed; women of childbearing potential not using contraception; women in breastfeeding; coagulation disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction or disappearance of actinic keratoses. Evaluation will be done by counting the number of actinic keratoses, immunohistochemistry, and histology of skin biopsies. As evaluation parameters will be used index tables for counting actinic keratoses, and description of histologic atypia and expression of p53 and Ki67 by pathologist. | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse effects related to the proposed treatment, appearance of skin tumors non-melanoma and tolerability. The evaluation will be questionmento by the researcher to the patient for adverse effects and tolerabiliade, and clinical evaluation for detection of new tumors by physical examination. | — |
Countries
Brazil
Contacts
Public ContactEliane Ferreira
Faculdade de Medicina de Botucatu - UNESP
Outcome results
None listed