Change in taste of patients undergoing chemotherapy treatment for breast and prostate cancer Dysgeusia
Conditions
Interventions
The change in taste (dysguesia) is one of the most frequent adverse effects of taxanes, however, there is no therapy to prevent or mitigate this condition. However, low intensity laser therapy (LBI) h
E02.594.540
Sponsors
Escola Cearense de Oncologia
Escola Cearense de Oncologia
Eligibility
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Patients older than 18 years with stage II, III and IV cancer free of previous chemotherapy treatment undergoing first adjuvant or neoadjuvant treatment with protocols of drugs of the taxane class (paclitaxel (Taxol®) or docetaxel (Taxotere® ) Chemotherapy protocols may or may not be associated with other drugs.
Exclusion criteria
Exclusion criteria: Patients with a history of radiotherapy in the head and neck, smokers, with anemia (hemoglobin less than 12 g / dl in women or 13 g / dl in men), untreated diabetes mellitus (from 200 mg / dL), using drugs that significantly alter the salivary flow, saliva composition, or taste (VRIES et al., 2018), in the use of central acting analgesics or anxiolytics and antidepressants. Patients who withdraw from treatment or study will be withdrawn from the study, requiring a change in the chemotherapy protocol with substitution of taxanes, discontinuing chemotherapy for any reason or developing systemic infections.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decrease and / or prevention of taste alteration through the application of laser therapy prior to chemotherapy, since in the study by VRIES et al. (2018) who observed a significant variation in taste loss scores in patients with breast cancer treated with chemotherapy from the pre-chemotherapy moment (22.67 ± 6.69) up to six months after the end of treatment (28.45 ± 4 , 08).Laser therapy has already been effective for the treatment and prevention of various alterations in the oral cavity; however, there are no studies addressing the use of this therapeutic measure for dysgeusia. | — |
Secondary
| Measure | Time frame |
|---|---|
| Laser therapy can reduce pain, discomfort, induce neural stimuli, as well as regenerate epithelium that in turn promotes cell repair. As the cause of dysgeusia is not yet elucidated, we will apply laser therapy in both red and infrared light in order to reach all the pathways that may cause this change. | — |
Countries
Brazil
Contacts
Public Contact;Cássia ;Nóbrega Malta
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Outcome results
None listed