Obesity
Conditions
Interventions
This is a parallel study, with two arms, double-blind, randomized, controlled, carried out with patients undergoing bariatric surgery. A group of 25 patients will receive three doses of testosterone u
E02.65
Sponsors
Hospital e Maternidade São Domingos
Universidade Federal do Maranhão
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Patients with Body Mass Index - BMI > 35; weighing up to 180 kg; with low testosterone levels (<350 ng/dl); classified as hypogonadal; who voluntarily agreed to participate in the research, in addition to understanding and consenting to participation through the TCLE (Free and Informed Consent Form)
Exclusion criteria
Exclusion criteria: Interest in fertility in the 6 months following therapy; diagnosis of active prostate or breast cancer; previous diagnosis of prostate cancer, with less than two years of curative treatment; previous diagnosis of breast cancer; severe voiding symptoms, translated through the IPSS score (International Prostatic Symptom Score) > 19; severe cardiopulmonary disease (eg unstable angina, recent myocardial infarction); personal or family history of thromboembolism; hematocrit above 48%; patients with implanted medical devices such as pacemakers or essential support devices such as monitors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate testosterone replacement in quality of life and sex in the weight loss process; It is expected a better quality of life and sexual score in the weight loss process after bariatric surgery with testosterone replacement | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate the impact of testosterone replacement on metabolic and inflammatory parameters; Testosterone replacement is expected to optimize the improvement of metabolic and inflammatory parameters;Evaluate the impact of testosterone replacement on the maintenance of muscle mass in the weight loss process; Testosterone replacement is expected to conserve muscle mass in the weight loss process | — |
Countries
Brazil
Contacts
Public ContactRodrigo Diniz
Universidade Federal do Maranhão
Outcome results
None listed