Pain
Conditions
Interventions
Patients will be allocated to receive 1 tablet of Allopurinol 300 mg tablet p.o. or 1 similar tablet of placebo at two time-points in the preoperative period: the night before surgery (22 h) and 1 h b
Drug
Sponsors
Hospital de Clinicas de Porto Alegre
Hospital de Clinicas de Porto Alegre
Eligibility
Sex/Gender
Female
Age
No minimum to 65 Years
Inclusion criteria
Inclusion criteria: Female gender; functional status of the American Society of Anesthesiologists (ASA) classes I or II; candidates for total abdominal hysterectomy
Exclusion criteria
Exclusion criteria: Illiterate patients or those who do not understand the Portuguese language; history of psychiatric or neurological symptoms; contraindication for spinal anesthesia; who refuse to participate in the study or who already participate in other studies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of 50% in pain scores, measured by a visual analogue pain scale, assessed in the first 24 hours after surgery.;Observed main outcome: a reduction of approximately 45% in pain scores was observed, measured by a visual analogue pain scale, assessed in the first 24 hours after surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected secondary outcome 1: Reduction of anxiety scores, measured by the Trait-State Anxiety Inventory for adults, assessed in the first 24 hours after surgery.;Observed secondary outcome 1: No significant reduction in anxiety scores was observed, measured using the Trait-State Anxiety Inventory for adults, assessed in the first 24 hours after surgery.;Expected secondary outcome 3: Reduction of 50% in pain scores, measured by verbal and numerical pain scales, assessed 30 days after surgery.;Observed secondary outcome 2: No significant reduction in pain scores was observed, measured by verbal and numerical pain scales, assessed 30 days after surgery.;Expected secondary outcome 4: Reduction of 50% in pain scores, measured by verbal and numerical pain scales, assessed 90 days after surgery.;Observed secondary outcome 3: No significant reduction in pain scores was observed, measured by verbal and numerical pain scales, assessed 90 days after surgery. | — |
Countries
Brazil
Contacts
Public ContactAndré Schmidt
Hospital de Clinicas de Porto Alegre
Outcome results
None listed