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Effect of physical exercise on motor parameters and blood markers in post-stroke patients

Effect of physical exercise on clinical-functional outcomes, modulation of epigenetic markers and levels of brain-derived neutrotrophic factor (BDNF) in peripheral blood in post-stroke patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-9phj2q
Enrollment
Unknown
Registered
2019-02-11
Start date
2018-04-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise therapy

Interventions

In the first stage of the study, the acute effect of exercise on balance, gait, muscle quality and blood biomarkers will be evaluated. Twelve volunteers will be part of the study, and these will be di
n = 12) will undergo a single session of physical exercise without the use of FES. Afterwards, blood collection and evaluation of muscle quality, gait and balance will be performed. This meeting will
n = 12), characteristic of a cross-over design. Afterwards, blood collection and evaluation of muscle quality, gait and balance will be performed again. This meeting will last approximately 1h 30 minu
Other
G11.427.410.698.277

Sponsors

Centro Universitário Metodista-IPA
Lead Sponsor
Centro Universitário Metodista-IPA
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion criteria adopted will be stroke for at least 6 months; be over 59 years old and have the ability to walk without using a bracing.

Exclusion criteria

Exclusion criteria: Individuals will be excluded if they use drugs containing HDAC inhibitors; such as Valproic Acid; other associated neurological diseases; orthopedic and / or musculoskeletal problems affecting gait; cognitive impairment identified by the Mini Mental State Examination (MMSE); disability the risk of deep venous thrombosis; have sensory deficits in the hemiparetic limb; cardiac pacemaker patients; pregnant women and individuals with metal plaques and cancer in the region of the fibula head (site that will be stimulated by FES).

Design outcomes

Primary

MeasureTime frame
A single exercise session enhances biomarkers by increasing the levels of histone and BDNF acetylation, assessed by commercial ELISA kits for colorimetric detection in peripheral blood of post-stroke patients.—

Secondary

MeasureTime frame
A single exercise session improves memory, lower limb muscle strength, and balance and quality of life in post-stroke patients, the Montreal Cognitive Assessment (MoCa) questionnaire, using the JAMAR® palmar gripper dynamometer and modified sphygmomanometer, through the Berg Balance Scale and the SF-36 Questionnaire.—

Countries

Brazil

Contacts

Public ContactViviane Elsner

Centro Universitário Metodista-IPA

elsner.viviane@gmail.com5551998651500

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 17, 2026