Inflammation, Gene Expression, Oxidative Stress, Lipid Metabolism, Insulin Resistance.
Conditions
Interventions
Application of a 12-week protocol of high-intensity interval training (HIIT) in severely obese patients aged 20-55 years, of both genders, and assisted by the Public Health System (SUS) in Joinville/S
antioxidant enzymes (catalase-CAT, glutathione peroxidase-GSH-Px and superoxide dismutase-SOD)
resting blood pressure
anthropometric measurements (body mass, height, Body Mass Index, and abdominal circumference)
body composition (electrical impedance)
thermographic images (Infrared Thermography)
cardiorespiratory fitness (6-minute Walk Test and Treadmill Exercise Test)
level of physical activity (International Physical Activity Questionnaire - IPAQ) and psychological stress (Perceived Stress Scale)
eating habits (24-hour dietary recall)
and socioeconomic profile (Brazil Criterion).
- Control group (CG): 50 severely obese individuals will undergo the same evaluations as GI (except for the Treadmill Exercise Test) and in the same peri
G11.427.410.698.277.311.250
Sponsors
Universidade da Região de Joinville
Hospital Regional Hans Dieter Schmidt
Eligibility
Age
20 Years to 55 Years
Inclusion criteria
Inclusion criteria: Both genders; being assisted by the Public Health System (SUS); age between 20 and 55 years; deliver the signed Informed Consent; do not participate in any other regular physical exercise program; do not present untreated or poorly controlled clinical disorders that could interfere with the variables of the study, such as altered levels of the TSH and free T4 hormones, even when taking medication; do not present untreated or poorly controlled clinical disorders, such as arterial hypertension, heart disease, or any other disease that could offer risk to the participant when practicing high-intensity exercises.
Exclusion criteria
Exclusion criteria: Any clinical complication during the intervention that influences the variables analyzed in this study or makes it impossible for the participant to continue the intervention and/or the evaluations, including orthopedic alterations or pain disorders; frequency in the HIIT program lower than 70% or absence from any evaluation performed in the study; use of appetite-suppressant medications; presence of diabetes; being menopausal, according to medical criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected that the HIIT program promotes improvements in the health parameters analyzed, in order to attenuate the chronic inflammation and the oxidative stress associated with obesity. | — |
Secondary
| Measure | Time frame |
|---|---|
| As a consequence of the regular exercise routine proposed to the research participants, it is expected that the severely obese patients will become aware of the importance of an active and healthy lifestyle for their overall health, as well as to prevent the recurrence of severe obesity after surgery. | — |
Countries
Brazil
Contacts
Public ContactDaniela de Lima
Universidade da Região de Joinville
Outcome results
None listed