Skip to content

Effects of 12-hour overnight fasting on metabolism and quality of life in overweight middle-aged women

Metabolic responses of overweight/obesity climacteric women according to feeding times

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-9n4sn5m
Enrollment
Unknown
Registered
2023-01-05
Start date
2021-08-02
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Interventions

40 overweight/obese women were evaluated during the climacteric, divided into 2 groups submitted to a diet plan for weight loss. The first group was instructed to eat until 11 pm and the second group
SP6.180.304

Sponsors

Centro de ciências da saúde - Universidade Federal de Pernambuco - UFPE
Lead Sponsor
Centro de ciências da saúde - Universidade Federal de Pernambuco - UFPE
Collaborator

Eligibility

Sex/Gender
Female
Age
40 Years to 59 Years

Inclusion criteria

Inclusion criteria: Female individuals; aged between 40 and 59 years; body mass index (BMI) between 25 kg/m2 and 39.9 kg/m2; waist circumference above 88 centimeters

Exclusion criteria

Exclusion criteria: Women with previous diagnosis of changes in the thyroid gland; impaired liver function; impaired kidney function; cardiovascular diseases; cancer; serious illness; using medication that alters weight; diagnosed with psychiatric illnesses. In addition, they will also be deleted; gastrointestinal problems; using drugs that may interfere with body composition

Design outcomes

Primary

MeasureTime frame
Expected outcome 1 To evaluate whether the temporal restriction of food during the night period brings greater metabolic benefits in overweight/obese women during the climacteric. The measurement of this outcome was performed through the analysis before and after the intervention of blood biochemical markers, namely: fasting blood glucose; insulinemia; glycated hemoglobin; triglycerides; total cholesterol and fractions; Mean Estimated Glycemia; Baseline cortisol; aspartate aminotransferase and alanine aminotransferase, performed using a Labmax 400® automatic analyzer and labtest® reagents. And anthropometric assessment before and after the intervention period, namely: body weight in kilograms measured on a Tanita BC601G® scale, height in meters measured using a Standard Sanny ES2030® stadiometer, hip and waist circumferences measured with a Sanny anthropometric measuring tape TR4013®. The techniques used for measurements followed the protocols proposed by Heyward & Stolarczyk (2000) for anthropometric assessments. Intragroup data analysis was performed using the paired Student's t test (parametric) or Wilcoxon (nonparametric). Comparisons of categorical variables were analyzed using Pearson's chi-square test. In order to find the expected outcome, the intensity of the final difference in the metabolic and anthropometric parameters between the groups considered a significance level of p<0.05 for all cases;Outcome found 1 The results showed, in both groups (control and restriction), a significant improvement in weight (final weight loss (kilograms): Control Group – 5.59% x Restriction Group – 6.1%) and in body composition (decrease percentage of body fat: Control Group – 4.35% x Restriction Group – 5.06%), in abdominal fat (percentage loss of waist circumference (cm): Control Group 11.96% x Restriction Group – 11.77% ), glucose metabolism (percentage decrease in fasting blood glucose (mg/dL): Control Group – 11.5% x Restriction Group – 11.57%) and lipid metabolism (pe

Secondary

MeasureTime frame
Secondary outcomes are not expected

Countries

Brazil

Contacts

Public ContactElizabeth Nascimento

Centro de ciências da saúde - Universidade Federal de Pernambuco - UFPE

elizabeth.nascimento2@ufpe.br+55(81)21268568

Outcome results

None listed

Source: REBEC (via WHO ICTRP)