Arterial Hypertension
Conditions
Interventions
A total of 40 hypertensive women were triple-blinded and randomized into 2 groups: probiotic (n=20) or placebo (n=20). In the probiotic group, participants were instructed to consume one sachet of Pro
Dietary supplement
G07.203.300.456.500
Sponsors
FarmoQuímica
Universidade Federal da Paraíba
Eligibility
Sex/Gender
Female
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: women diagnosed with primary systemic arterial hypertension (SAH) and aged 20 to 50 years.
Exclusion criteria
Exclusion criteria: Age 50 years; Smoking; Patients with other associated morbidities with the exception of Diabetes Mellitus; Patients with a history of angina, acute coronary syndrome, changes in left ventricular ejection fraction; Patients with changes in liver enzyme levels or kidney failure (creatinine> 1.5 mg / dL); Use of medications other than antihypertensives or hypoglycemics; Patient undergoing steroid or anticoagulant treatment, using food supplements, with infections or neoplasia or other chronic pathology known; Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effects of probiotic supplementation on blood pressure levels (by sphygmomanometry), heart rate and heart rate variability (by electrocardiogram) were evaluated. After 8 weeks of supplementation with probiotics, hypertensive patients show a 5 mmHg reduction in systolic blood pressure levels and 2 mmHg in diastolic blood pressure levels. In addition, at the end of probiotic supplementation, hypertensive women showed a significant reduction in cardiac autonomic modulation, observed by a 33.3% reduction in the LF / HF or sympathetic-vagal balance. | — |
Secondary
| Measure | Time frame |
|---|---|
| The effects of probiotic supplementation on the biochemical variables (by enzymatic methods), and on the intestinal and fecal microbiota (using the breath test and microorganism count) were evaluated. After 8 weeks of supplementation with probiotics, hypertensive patients present a significant reduction in serum glucose levels (9%) and total cholesterol (11.4%) and an increase in HDL (14%). The serum levels of triglycerides, creatinine, urea, LDL, VDL, c-reactive protein and malondialdehyde were not altered. In addition, after 8 weeks of treatment, there was a significant increase in the fecal count of lactobacillus (43.7%), but with no change in the counts of bifidobacteria, enterobacteria and bacteriodes. Bacterial overgrowth reduced from 3 patients before the intervention to 1 patients after the intervention. | — |
Countries
Brazil
Contacts
Public ContactJosé Luiz Alves
Universidade Federal da Paraíba
Outcome results
None listed