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Influence of vitamin B1 suplementation in oxidative stress, energetic metabolism and mortality among patients with septic shock

Influence of thiamine suplementation in oxidative stress, energetic metabolism and mortality among patients with septic shock

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-9m6bny
Enrollment
Unknown
Registered
2018-09-20
Start date
2018-06-04
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic shock

Interventions

This will be a prospective, controlled, double-blind, randomized trial. The sample size number obtained was 116 patients. Patients will be randomized by the project coordinator (professor) and alloca
D02.886.675.900

Sponsors

Faculdade de Medicina de Botucatu
Lead Sponsor
Faculdade de Medicina de Botucatu
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: age over 18 years; both sexes; hospitalized with the diagnosis of septic shock at the Intensive Care Unit of Hospital das Clínicas of Botucatu Medical School; signing the Free and Informed Consent Term.

Exclusion criteria

Exclusion criteria: Delayed diagnosis of septic shock (time greater than 24 h); pregnancy; noradrenaline dose > 2.0 mcg/kg/min, vasopressor-dependence for less than 24 h; patients with clinical indication of supplementation thiamine; confirmed encephalic death; patients in palliative care; association with other types of shock (cardiogenic, hemorrhagic or hypovolemic).

Design outcomes

Primary

MeasureTime frame
The primary outcome will be mortality in the Intensive Care Unit (ICU) and hospital mortality. Patients will be monitored daily during their ICU and hospital stay, until discharge or death.—

Secondary

MeasureTime frame
Length of ICU and hospital stay. Patients will be monitored daily during their ICU and hospital stay, until discharge or death. The total length of stay will be counted in days.;Duration of mechanical ventilation. Patients will be monitored daily during their ICU and hospital stay, and the duration of mechanical ventilation will be counted in days, considering the period between the first and last day of use.;Duration of vasopressor use. Patients will be monitored daily during their ICU and hospital stay, and the duration of vasopressor need will be counted in days, considering the period between the first and last day of use.—

Countries

Brazil

Contacts

Public ContactAmanda Pereira

Faculdade de Medicina de Botucatu

amandagomesp@yahoo.com+55-018-996481800

Outcome results

None listed

Source: REBEC (via WHO ICTRP)