Initial filling of 0.9% Sodium Chloride versus 20% Albumin in preventing blood pressure drop in patients with Acute Renal Failure during hemodialysis: a comparative clinical study

Initial priming of 0.9% Sodium Chloride vs 20% Albumin in preventing hemodynamic instability in patients with Acute Kidney Injury during hemodialysis: a randomized clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

REBEC

Registry ID

RBR-9m634y8

Enrollment

Unknown

Registered

2025-04-24

Start date

2025-04-01

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury

Interventions

This is a prospective randomized clinical trial that will evaluate the prevention of hemodynamic instability during prolonged hemodialysis sessions in patients with acute kidney injury associated with

E02.319.267

Eligibility

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Men and women; over 18 years old; with acute kidney injury; admitted to the intensive care unit using norepinephrine at a dose of 0.3 to 0.6 ucg/kg/min; and undergoing prolonged hemodialysis for at least 3 sessions

Exclusion criteria

Exclusion criteria: Patients under 18 years of age; and treated with less than two sessions of prolonged hemodialysis

Design outcomes

Primary

Measure	Time frame
Improvement in metabolic control is expected after 3 sessions of prolonged hemodialysis (urea, creatinine, potassium and bicarbonate levels), assessed through blood collection. Improvement in volume control is expected after 3 sessions of prolonged hemodialysis assessed through cumulative fluid balance. To assess the recovery of renal function through laboratory tests collected at the beginning and end of the study	—

Measure

Time frame

Improvement in metabolic control is expected after 3 sessions of prolonged hemodialysis (urea, creatinine, potassium and bicarbonate levels), assessed through blood collection. Improvement in volume control is expected after 3 sessions of prolonged hemodialysis assessed through cumulative fluid balance. To assess the recovery of renal function through laboratory tests collected at the beginning and end of the study

—

Secondary

Measure	Time frame
has no secondary outcome	—

Countries

Brazil

Contacts

Public ContactSimone Ferreira

Hospital das Clínicas da Faculdade de Medicina de Botucatu da Universidade Estadual Paulista

enfermeirasi2007@yahoo.com.br+55(014)996051969

Outcome results

None listed

Source: REBEC (via WHO ICTRP)