Type 2 diabetes. Beta-cell Dysfunction. Bariatric Surgery.
Conditions
Interventions
Controlled study: one experimental group and two control groups. Experimental group: 20 obese grade I and II patients with type 2 diabetes who underwent biliopancreatic diversion surgery. Evaluated p
procedure/surgery
Sponsors
Universidade Estadual de Campinas
Universidade Estadual de Campinas
Eligibility
Sex/Gender
Female
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Female, older than 20 years, being in premenopausal period, type 2 diabetic patient using only oral anti-diabetic medication or no medication for diabetes, weight variation less than 5% in the last 3 months; capacity to understand the procedures of the study and voluntarily agree to participate in the study by signing the consent form.
Exclusion criteria
Exclusion criteria: Patients taking insulin or drugs with effects on insulin secretion; BMI greater than or equal to 18.5 kg / m²; history of liver disease such as cirrhosis or chronic active hepatitis; alteration of renal function, a recent history of cancer, use of oral corticosteroids or injected by more than 14 consecutive days in the last 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute improvement on beta-cell function one month after biliopancreatic diversion surgery assessed by hyperglycemic clamp test and by the oral glucose tolerance test | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement on beta-cell function one year after biliopancreatic diversion surgery assessed by hyperglycemic clamp test and by the oral glucose tolerance test | — |
Countries
Brazil
Contacts
Public ContactBruno Geloneze
Universidade Estadual de Campinas
Outcome results
None listed