Intubation and hemodynamic
Conditions
Interventions
One hour before surgery, all patients selected will receive 15 mg of midazolam. Anesthesiologist will perform standard anesthetic induction using 3 mcg / kg of fentanyl, 2 mg / kg of propofol and 0.5
the second group will receive 1.5 mg / kg esmolol
and the third group will be the control group, which will use only 0.9% saline solution. After endotracheal intubation, all patients will be ventilated within the first 10 minutes at a tidal volume of
Drug
Sponsors
Universidade do Sul de Santa Catarina
Hospital Nossa Senhora da Conceição
Eligibility
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Functional class I and II patients, according to the American Society of Anesthesiologists (ASA); submitted to elective surgery; of both sexes; aged between 18 and 65 years; who agree to participate in the study
Exclusion criteria
Exclusion criteria: Patients with difficult airway; obesity with BMI> 35; in the use of beta-blockers or calcium channel blockers; with heart rate less than 60 bpm; cardiac arrhythmias, renal dysfunction, airway hyperreactivity, hypersensitivity to esmolol or magnesium sulfate; and pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemodynamic stability with maintenance of blood pressure and heart rate baseline, assessed by cardioscopy and noninvasive blood pressure. The 20% variation of pressure levels and heart rate relative to the low levels is considered an unfavorable outcome. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are not expected | — |
Countries
Brazil
Contacts
Public ContactFabiana Schuelter-Trevisol
Universidade do Sul de Santa Catarina
Outcome results
None listed