postoperative pain
Conditions
Interventions
Twenty patients will be submitted to bilateral and symmetrical lower impacted third molar surgery in two sessions, with minimum interval of 30 days and will be divided into two groups (A and B), in a
Drug
HP3.095.471
HP1.007.148.238
Sponsors
Faculdade de Ciências da Saúde da Universidade de Brasília
Faculdade de Ciências da Saúde da Universidade de Brasília
Eligibility
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients older than 18 years who agree to participate in research, with good general health, without any medicine intake in the last 15 days (except contraceptives), patients who have indicated bilateral extraction of impacted lower third molar, in similar conditions on both sides.
Exclusion criteria
Exclusion criteria: Patients who do not want to participate in the study, patients who have used any drug in the last 15 days (except contraceptives), pregnancy, breastfeeding, and presence of pericoronitis related to lower third molar, patients who report history of allergies or adverse drug effects used in the study, actual or past history of ulcer disease or gastrointestinal bleeding, renal failure, advanced liver disease and coagulopathy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Outcome expected: Further reduction of postoperative pain in the group that received multiple doses of preoperative ibuprofen in relation to the group which received single preoperative dose of ibuprofen at times 3, 8 and 24 hours after surgery. Visual analogue scale will be used for evaluate the reduction of pain. The reduction of at least 15 millimeters at visual analog scale for determining the expected outcome will be considered.;Primary outcome found: It was observed more relief of postoperative pain using ibuprofen preoperative multiple doses compared to use of ibuprofen preoperative single-dose, 3 and 8 hours after surgery (2.2 ± 2.1 vs. 3 7 ± 2.9, 2.7 ± 2.2 vs. 3.7 ± 3.4, 3 hours and 8 hours, respectively, p <0.05). For verification, it was used the reduction at least of 15 millimeters on the visual analog scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary Outcome expected (1): further reducing the induced hyperalgesia, measured 24 hours after surgery, in the group that received ibuprofen preoperative multiple doses compared to the group that received ibuprofen preoperative single dose. Semmes Weistein filaments will be applied in two intraoral points (one point on the occlusal surfaces of the surgical cavity sutured - P1 and another point on the vestibular region of the extracted third molar - P2) immediately before (baseline) and 24 hours after surgery, to assess tissular hyperalgesia. For verification, it will be noted the smaller diameter filament whose application at right angles in the tested surface, followed by its fold resulting in reports of pain by the patient. The result will express as the logarithm of the difference between 24 hours and baseline measurements.;Secondary Outcome found (1): there was similar reduction of induced hyperalgesia, measured 24 hours after surgery, in both groups. Semmes Weinstein filaments were applied to evaluate tissular hyperalgesia in two points (one point on the occlusal surfaces of the surgical cavity sutured - P1 and another point on the vestibular region of the extracted third molar - P2) immediately before (baseline measurement ) and 24 hours after surgery. The smaller diameter filament whose application at right angles in the tested surface, followed by its fold resulted in reports of pain by the patient was recorded for verification. The result was expressed as the logarithm of the difference between 24 hours and baseline measurements (P1 = 2.08 ± 0.56 vs. 1.97 ± 0.72, P = 0.43, P2 = 1.86 ± 0.84 vs . 1.86 ± 0.85, P = 0.98, single-dose versus multiple doses, respectively).;Secondary Outcome expected (2): lower reduction of mouth opening degree in the group that received ibuprofen preoperative multiple doses compared to the group that received ibuprofen single-dose preoperative, 24 hours after surgery. Mouth opening (distance in millimeters between the mes | — |
Countries
Brazil
Contacts
Public ContactErica;Sara Lia;Vieira
Faculdade de Ciências da Saúde da Universidade de Brasília;Faculdade de Ciências da Saúde da Universidade de Brasília
Outcome results
None listed