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Fluoride present in toothpaste as an indicator of its availability in saliva

Chemically soluble fluoride found in toothpaste as a predictor of fluoride bioavailability in saliva

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-9hspyy
Enrollment
Unknown
Registered
2019-02-06
Start date
2018-05-02
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental carie

Interventions

All participants will be submitted to five groups of studies: fluoride placebo dentifrice - Negative Placebo, a commercial dentifrice containing 1450 ppm F, commercial dentifrice submitted to accelera
Other

Sponsors

Faculdade de Odontologia de Piracicaba
Lead Sponsor
Faculdade de Odontologia de Piracicaba
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Good general and oral health; Salivary flow unstimulated within normalities.

Exclusion criteria

Exclusion criteria: Participants using orthodontic appliances; Participants who use medications that affect the salivary flow.

Design outcomes

Primary

MeasureTime frame
Expected outcome 1: Evaluation of the saliva-soluble fluoride concentration (bioavailable) after brushing with dentifrices with different concentrations of soluble fluoride, evaluated by analyzing the fluoride concentration in the saliva and then calculating the area under the curve, with a variation of hair 5% between the groups with the closest concentrations.;Outcome 1: A correlation between soluble fluoride in toothpaste and bioavailable fluoride in saliva, evaluated by statistical test with concentrations of soluble fluoride in the toothpaste and saliva, presenting a high correlation.

Secondary

MeasureTime frame
Secondary outcomes are not expected

Countries

Brazil

Contacts

Public ContactCamila Coelho

Faculdade de Odontologia de Piracicaba

csscoehoo@gmail.com+55-019-21065303

Outcome results

None listed

Source: REBEC (via WHO ICTRP)