Other surgical procedures or interventions Pharmacological substance with systemic action, unspecified
Conditions
Interventions
This is a randomized, double-blind clinical trial involving 105 male and female patients scheduled for elective laparoscopic cholecystectomy. The study will have three arms: 35 x 35 x 35 (dextrocetami
Sponsors
Hospital Universitário Gaffree e Guinle
Hospital Universitário Gaffree e Guinle
Eligibility
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients aged 18 to 70 years with an American Society of Anesthesiologists Physical Status classification of 1 or 2 who require surgical treatment for symptomatic cholecystitis
Exclusion criteria
Exclusion criteria: Conversion to open surgery; surgery lasting longer than 3 hours; use of illicit drugs; use of prescription medications known to induce the cytochrome complex; patients with renal and hepatic insufficiency; chronic users of corticosteroids and nonsteroidal anti-inflammatory drugs; a body mass index greater than or equal to 40; heart failure; valvular heart disease; or ischemic heart disease; and use of tricyclic antidepressants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected that there will be at least a 10% reduction in perioperative interleukin-6 (IL-6) and interferon-gamma (INF-?) levels in the intervention group | — |
Secondary
| Measure | Time frame |
|---|---|
| At least a 10% reduction in pain scores among patients in the intervention group during the postoperative period | — |
Countries
BR
Contacts
Public ContactGustavo Silva
Hospital Universitário Gaffree e Guinle
Outcome results
None listed