Intestinal constipation
Conditions
Interventions
A double-blind, randomized, placebo-controlled clinical trial with a four-week intervention period was carried out over four weeks. Women aged 20 to 59 years, diagnosed with functional constipation, w
G07.203.300.456.500
Sponsors
Faculdade de Nutrição - Universidade Federal de Goiás
Faculdade de Nutrição - Universidade Federal de Goiás
Eligibility
Sex/Gender
Female
Age
20 Years to 59 Years
Inclusion criteria
Inclusion criteria: Women; age between 20 and 59; self-reported stool types two to four on the Bristol Stool Scale; who had at least two of the criteria on the Rome IV Index
Exclusion criteria
Exclusion criteria: Women undergoing bariatric surgery; history of persistent diarrhea or inflammatory bowel disease; irritable bowel syndrome; vegetarian or on a diet; regular alcohol consumption (> 7 drinks/week); smokers; moderate or vigorous exercise > 3 h/week; use of antibiotics, laxatives, immunosuppressants, diuretics and antacids within one month before the start of the intervention; use of probiotic, prebiotic or symbiotic supplements; use of fermented foods during this same period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We expect to observe at least a 10% increase in evacuation frequency, as assessed by the ROMA IV questionnaire, after the intervention with the probiotic mix compared to the placebo group.;After four weeks of probiotic supplementation, 63.16% of individuals in the intervention group experienced a reversal of constipation, compared to 36.36% in the placebo group | — |
Secondary
| Measure | Time frame |
|---|---|
| Severe constipation (Bristol scale type 1) was extinguished in the probiotic group, whereas it persisted in 27.3% of the placebo group ;The placebo group exhibited significantly lower microbial diversity compared to the probiotic group at the end of intervention | — |
Countries
Brazil
Contacts
Public ContactJoão Mota
Universidade Federal de Goiás
Outcome results
None listed