Complete Upper and Lower Limb Rehabilitation System for Post-Stroke Patients Using Brain-Computer Interface, Rehabilitation Robots, and Brain Stimulation Techniques

Complete Rehabilitation System for Upper and Lower Limbs in Post-Stroke Patients Using Brain-Computer Interface, Robotic Devices, and Neurostimulation Techniques

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-9fmycc5

Enrollment

Registered

2026-07-20

Start date

2026-03-25

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurological Rehabilitation

Interventions

This is a four-arm, single-blind, randomized controlled clinical trial. The proposed methodology comprises a series of intermediate objectives that will be accomplished through five research stages (E

Eligibility

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Subcortical or cortical Stroke (single event); Lower and/or upper limb paralysis; At least 3 months since the Stroke; Age between 18 and 80 years; Availability to use TMS equipment; Ability to understand and follow instructions

Exclusion criteria

Exclusion criteria: Absence of acute psychiatric or neurological condition other than stroke; Absence of cerebellar lesion or bilateral motor deficit; Not pregnant; Absence of claustrophobia; No epilepsy or use of epilepsy medication in the last 6 months

Design outcomes

Primary

Measure	Time frame
It is expected that chronic post-stroke patients in Group I will demonstrate a faster recovery of ipsilesional corticospinal tract integrity and motor function of the paralyzed limbs compared to patients in Group II, as verified through the application of the proposed protocol, which includes Functional Electrical Stimulation (FES) and neuromodulation techniques (tDCS, tACS, TMS) combined with BCI-controlled robotic devices, focusing on perilesional mu (µ, 8–12 Hz) and beta (ß, 13–30 Hz) rhythms. An increase in functional anisotropy and recovery of Motor Evoked Potentials (MEPs) in the paralyzed limbs is expected to be observed, along with direct evidence of modulation of mu and beta rhythms associated with the perilesional motor task in Group I compared to Group II (placebo), after a 4-week training period.	—

Measure

Time frame

It is expected that chronic post-stroke patients in Group I will demonstrate a faster recovery of ipsilesional corticospinal tract integrity and motor function of the paralyzed limbs compared to patients in Group II, as verified through the application of the proposed protocol, which includes Functional Electrical Stimulation (FES) and neuromodulation techniques (tDCS, tACS, TMS) combined with BCI-controlled robotic devices, focusing on perilesional mu (µ, 8–12 Hz) and beta (ß, 13–30 Hz) rhythms. An increase in functional anisotropy and recovery of Motor Evoked Potentials (MEPs) in the paralyzed limbs is expected to be observed, along with direct evidence of modulation of mu and beta rhythms associated with the perilesional motor task in Group I compared to Group II (placebo), after a 4-week training period.

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Secondary

Measure	Time frame
It is intended to invest in the development and implementation of future treatment protocols and to disseminate the results to the scientific community through the analysis of the primary outcomes obtained in this study. The study is expected to contribute to the development of new protocols and to accelerate the motor rehabilitation of post-stroke individuals with neuromotor dysfunctions affecting the upper and lower limbs, based on the elucidation of the functional role of brain oscillations related to the motor area.	—

Measure

Time frame

It is intended to invest in the development and implementation of future treatment protocols and to disseminate the results to the scientific community through the analysis of the primary outcomes obtained in this study. The study is expected to contribute to the development of new protocols and to accelerate the motor rehabilitation of post-stroke individuals with neuromotor dysfunctions affecting the upper and lower limbs, based on the elucidation of the functional role of brain oscillations related to the motor area.

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Countries

Contacts

Public ContactSheila Schreider

Universidade Federal do Espírito Santo

sheiladaluz@gmail.com+55-27-999073695

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Aug 10, 2026