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Comparison of Leucine-Rich Alpha-2-Glycoprotein-1 (LRG-1) blood Levels Between Patients With and Without Appendicitis

Diagnosis of Appendicitis by Analysis of Peripheral Blood - Project APPENDIX - Appendix: Appendicitis Diagnosis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
REBEC
Registry ID
RBR-9dxqbk
Enrollment
Unknown
Registered
2020-07-02
Start date
2011-03-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute appendicitis, unspecified

Interventions

28 patients with acute abdominal pain and who consulted in the emergency of the Hospital de Clínicas de Porto Alegre will have a blood sample obtained and followed up prospectively to identify their o
Biological/vaccine
E01.370.225

Sponsors

Hospital de Clínicas de Porto Alegre
Lead Sponsor
Hospital de Clínicas de Porto Alegre
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Recent abdominal pain (less than 30 days) with at least one more of the other criteria; pain in the right iliac region; pain migrating; nausea or vomiting before vomiting; psoas sign; fever; rebound tenderness (Blumberg sign); abdominal rigidity; no previous similar pain; pain to digital rectal examination; anorexia.

Exclusion criteria

Exclusion criteria: Refusal to participate in the study; have already undergone appendectomy.

Design outcomes

Primary

MeasureTime frame
Presentation of the expected outcome: Quantitatively assess plasma LRG1 levels. Presentation of the method used to verify the expected outcome: ELISA. Presentation of the parameters (ng / ml) used to verify whether the outcome actually occurred: We will quantify the plasma LRG1 concentration (in ng / ml) in patients with and without the diagnosis of acute appendicitis. We expect to see a difference of 53 ng / ml in the group without appendicitis to 95 ng / ml for the group with appendicitis, having a 95% power and an alpha error of 1%

Secondary

MeasureTime frame
no secondary outcomes are sought

Countries

Brazil

Contacts

Public ContactRicardo Savaris

Universidade Federal do Rio Grande do Sul

rsavaris@hpca.edu.br+ 55 51 33598117

Outcome results

None listed

Source: REBEC (via WHO ICTRP)