Peri-Implantitis
Conditions
Interventions
Intervention in all groups is the surgical treatment of peri-implantitis (totaling 60 treated implants). Before surgical treatment of peri-implantitis, all patients will be submitted to non-surgical m
Procedure/surgery
Sponsors
Universidade Federal do Rio Grande do Norte
Universidade Guarulhos
Universidade Paulista
Eligibility
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Volunteers of both sexes; age over 18 years; toothless units, partial or total; patients with single or multiple osseointegrated implants rehabilitated with a minimum period of 12 months; patients with at least one implant with the clinical diagnosis of peri-implantitis according to the criteria of Mombelli (1999).
Exclusion criteria
Exclusion criteria: Volunteers with severe psychosomatic illnesses that prevent good oral hygiene; diagnosis of systemic conditions that make it impossible to undergo a surgical procedure; hallucinogenic or narcotic drug users; history of antibiotic and / or anti-inflammatory therapy 3 months before the initial evaluation visit; carriers of diseases that cause severe impairment of the immune system.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main primary outcome: Decrease in the degree of peri-implant inflammation and the depth of probing, determined by probing at the beginning of the study and at the end of the study.;Expected primary outcome 2: Maintenance of bone level, determined by measuring in millimeters with a ruler on digital periapical radiography at the beginning of the study and at the end of the study.;Expected primary outcome 3: Decrease in visible biofilm, determined by the presence or absence of biofilm on the faces of teeth and prostheses at the beginning of the study and at the end of the study. | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected secondary outcome 1: Maintenance of the band of keratinized mucosa, verified through the distance from the mucogingival junction to the gingival margin, measured at the midpoint of the buccal surface of teeth and implants; measured in millimeters with the aid of a millimeter probe; assessed before surgery, 6 months, 12 months and 1 year after the intervention; from the observation of the variation in the pre and post-intervention measurements.;Expected secondary outcome 2: Reduction of the oxidative stress marker malondialdehyde, verified through the reaction with thiobarbituric acid and production of a pink pigment allowing the analysis of the standard curve. The measurement will be made through a spectrophotometer, from the saliva collected on the day of the surgical procedure and 12 months after the surgery, to perform the comparison.;Expected secondary outcome 3: Reduction of the oxidative stress marker superoxide dismutase, verified by assessing its ability to inhibit the photochemical reduction of nitro-tetrazolium blue. The measurement will be made through a spectrophotometer, from the saliva collected on the day of the surgical procedure and 12 months after the surgery, to perform the comparison.;Expected secondary outcome 4: Reduction of the oxidative stress marker total antioxidant capacity, capable of measuring the antioxidant capacity of virtually all components of a biological sample. The measurement will be made through a spectrophotometer, from the saliva collected on the day of the surgical procedure and 12 months after the surgery, to perform the comparison.;Expected secondary outcome 5: Reduction of the oxidative stress marker glutathione peroxidase, verified through the consumption of Nicotinamide Adenine Dinucleotide Phosphate using the extinction length change (340 nm). The measurement will be made through a spectrophotometer, from the saliva collected on the day of the surgical procedure and 12 months after the surgery, to perform the | — |
Countries
Brazil
Contacts
Public ContactBruno César de Gurgel
Universidade Federal do Rio Grande do Norte
Outcome results
None listed