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Effects of Duloxetine on muscle loss associated with knee arthrosis

Effects of Duloxetine on Sarcopenia associated with knee Osteoarthritis: a randomized clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-9c72hyz
Enrollment
Unknown
Registered
2021-01-04
Start date
2017-03-16
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis

Interventions

Group Duloxetine: 24 participants with knee osteoarthritis will receive orientation for home-based physical activity to be performed at least three times per week for 30 minutes and 1 capsule of dulox
D02.886.778.260
G11.427.410.698.277

Sponsors

Sociedade Brasileira de Reumatologia
Lead Sponsor
Hospital de Clínicas de Porto Alegre
Collaborator

Eligibility

Age
40 Years to 75 Years

Inclusion criteria

Inclusion criteria: Osteoarthritis; Pain>7 (visual analog scale); Low/moderate physical performance

Exclusion criteria

Exclusion criteria: Contra-indications to study's interventions; Inability to walk

Design outcomes

Primary

MeasureTime frame
To evaluate an increase on physical performance by Short Physical Performance Battery in 12 weeks, by observing a variation of at least 0.8 between pre and post-intervention measures.—

Secondary

MeasureTime frame
Muscle mass assessed by appendicular skeletal muscle mass index on dual-energy X-ray absorptiometry ;Muscle strength assessed by maximal isometric voluntary contraction on knee extensor chair—

Countries

Brazil

Contacts

Public ContactRafael Chakr
+55-51-33598340

Outcome results

None listed

Source: REBEC (via WHO ICTRP)