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Randomized split-mouth clinical trial of Home Dental Whitening with 10%, 15%, and 20% Carbamide Peroxide

Comparative clinical split-mouth analysis of at-Home Dental Bleaching with 10%, 15%, and 20% Carbamide Peroxide

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-9bxs5rf
Enrollment
Unknown
Registered
2025-12-04
Start date
2023-05-10
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Sensitivity

Interventions

This is a triple-blind, three-arm, randomized controlled clinical trial involving 51 participants, who were randomly allocated into three intervention groups (n = 17 per group). The participants were
Group B: 10% carbamide peroxide vs. 20% carbamide peroxide
and Group C: 15% carbamide peroxide vs. 20% carbamide peroxide. Randomization was performed by drawing coded tokens from an unmarked container. The participants were unaware of the concentrations used

Sponsors

Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul
Lead Sponsor
Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul
Collaborator

Eligibility

Age
18 Years to 30 Years

Inclusion criteria

Inclusion criteria: Absence of carious lesions, absence of defective and/or fractured restorations, absence of periodontal disease or teeth with spontaneous pain; presence of healthy oral soft tissues and good systemic condition; no history of adverse reactions to peroxides; and teeth with a shade of at least A2; any gender will be accepted; participants must be between 18 and 30 years of age

Exclusion criteria

Exclusion criteria: Presence of restorations on the buccal surfaces of central and lateral incisors, canines, and premolars; use of fixed orthodontic appliances or residual resin on the buccal surface after appliance removal; pregnant or breastfeeding women; smokers and individuals with routine alcohol consumption; those who do not agree to sign the informed consent form; those who have previously undergone bleaching treatment; and individuals with teeth presenting tetracycline staining, fluorosis, or non-vital teeth

Design outcomes

Primary

MeasureTime frame
Expected outcome: increased effectiveness of dental bleaching associated with higher product concentration.

Secondary

MeasureTime frame
Increased dentin sensitivity associated with higher product concentration

Countries

Brazil

Contacts

Public ContactPedro Melecchi

Universidade Federal do Rio Grande do Sul

pedromelecchi@hotmail.com+55(51) 3308-5010

Outcome results

None listed

Source: REBEC (via WHO ICTRP)